External Oblique Intercostal Plane Block for Liver Transplantation Recipient

NCT07233083 | Recruiting

• 1 other identifier: anestezi 5
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

Postoperative pain management is one of the key factors in improving rehabilitation and accelerating recovery. The external oblique intercostal plane block can be used to provide abdominal wall analgesia for effective pain control in abdominal surgery. The aim of this study is to investigate the postoperative analgesic efficacy of the external oblique intercostal plane block in liver transplant recipients. The investigators will compare a group receiving the external oblique intercostal plane block with a control group to determine whether this block provides effective postoperative analgesia in liver transplant recipients.

Conditions

Liver Transplantation; Recipients of Liver Transplant; Postoperative Pain

Outcome Measures

Primary Outcomes (1)

• The amount of morphine required by the patient and given by the device will be recorded for the first 24 hours

  Postoperative 24 hours

Secondary Outcomes (3)

• Postoperative visual analog scale scores

  Postoperative 24 hours

• Rescue analgesic drug consumption

  postoperative 24 hours

• Incidence of postoperative nausea and vomiting

  postoperative 24 hours

Study Arms (2)

External oblique intercostal plane block group

ACTIVE COMPARATOR

The patients in the External Oblique Intercostal Plane Block group will receive bilateral external oblique intercostal plane block and patient controlled analgesia (PCA) with morphine for postoperative analgesia.

Other: External Oblique Intercostal Plane Block

Control Group

SHAM COMPARATOR

The patients in the Control group will not receive any regional block and will receive patient controlled analgesia (PCA) with morphine for postoperative analgesia.

Other: Sham Procedure

Interventions

Sham Procedure OTHER

Sham Block (Ultrasound probe placement without needle insertion or injection)

Control Group

External Oblique Intercostal Plane Block OTHER

External oblique intercostal plane block will be administered at the end of the surgery and after skin closure

External oblique intercostal plane block group

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Adult patients aged 18 to 75 years
• Scheduled for elective orthotopic liver transplantation (living or deceased donor)
• J-shaped or Mercedes incision planned
• ASA physical status III-IV
• Normal or acceptable coagulation profile at the time of block application (INR ≤ 1.5, platelet count ≥ 50,000/mm³, fibrinogen ≥ 150 mg/dL)
• Able to provide written informed consent

You may not qualify if:

• Coagulopathy at the time of block application (INR \> 1.5, platelet count \< 50,000/mm³, or fibrinogen \< 150 mg/dL)
• Known allergy or hypersensitivity to local anesthetics (amide group)
• Local infection or skin lesion at the block injection site
• Severe hemodynamic instability requiring high-dose vasopressor support
• Chronic opioid use (≥30 mg oral morphine equivalents per day for ≥30 days before surgery)
• Severe hepatic encephalopathy or cognitive impairment preventing use of PCA or pain scoring
• Emergency or re-transplantation surgery

Sponsors & Collaborators

• Istinye University: lead

Study Sites (1)

istinye University

Istanbul, Turkey (Türkiye)

RECRUITING

MeSH Terms

Conditions

Pain, Postoperative

Condition Hierarchy (Ancestors)

Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Pain; Neurologic Manifestations; Signs and Symptoms

Central Study Contacts

Taylan Sahin

CONTACT

+905452303111; taylansah@hotmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 14, 2025
• First Posted: November 18, 2025
• Study Start: December 22, 2025
• Primary Completion: May 1, 2026
• Study Completion (Estimated): June 1, 2026
• Last Updated: January 8, 2026

Record last verified: 2025-11

Locations

TU (1)