Erector Spinae Plane Block Versus External Oblique Intercostal Plane Block for Analgesia in Open Cholecystectomy

NCT07533279 | Not Yet Recruiting

• 1 other identifier: MD-37-2024
• Study Type: interventional
• Target: 66
• Locations: 0 countries
• Sites: N/A

Brief Summary

This randomized controlled trial aims to compare the analgesic efficacy of bilateral ultrasound-guided erector spinae plane block (ESPB) versus bilateral external oblique intercostal plane (EOI) block in patients undergoing open cholecystectomy. Patients will be randomly allocated into two groups to receive either ESPB or EOI block in addition to standard general anesthesia. The primary outcome is postoperative pain score assessed using the Numerical Rating Scale (NRS) at 2 hours after surgery. Secondary outcomes include intraoperative opioid consumption, postoperative nalbuphine requirements, time to first analgesic request, and hemodynamic changes. This study seeks to determine the more effective regional anesthesia technique for improving perioperative analgesia in open cholecystectomy.

Conditions

Cholecystectomy; Postoperative Pain; Erector Spinae Plane Block; Regional Anesthesia

Outcome Measures

Primary Outcomes (1)

• Postoperative Pain Score (VAS)

  Postoperative pain will be assessed using the Visual Analog Scale (VAS) at rest and during movement.

  Within the first 24 hours postoperatively

Secondary Outcomes (3)

• Total Opioid Consumption

  First 24 hours postoperatively

• Time to First Analgesic Request

  Within 24 hours postoperatively

• Postoperative Complications

  Within 24 hours postoperatively

Study Arms (2)

Erector Spinae Plane Block Group

EXPERIMENTAL

Participants in this group will receive bilateral erector spinae plane block using local anesthetic for postoperative analgesia following open cholecystectomy.

Procedure: Erector Spinae Plane Block

External Oblique Intercostal Plane Block Group

EXPERIMENTAL

Participants in this group will receive bilateral external oblique intercostal plane block using local anesthetic for postoperative analgesia following open cholecystectomy.

Procedure: External Oblique Intercostal Plane Block

Interventions

Erector Spinae Plane Block PROCEDURE

Bilateral erector spinae plane block will be performed under ultrasound guidance using local anesthetic prior to surgical incision to provide postoperative analgesia.

Erector Spinae Plane Block Group

External Oblique Intercostal Plane Block PROCEDURE

Bilateral external oblique intercostal plane block will be performed under ultrasound guidance using local anesthetic prior to surgical incision to provide postoperative analgesia.

External Oblique Intercostal Plane Block Group

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Adult patients aged 18-65 years.
• Patients scheduled for elective open cholecystectomy.
• American Society of Anesthesiologists (ASA) physical status I-II.
• Patients who provide informed consent.

You may not qualify if:

• Patient refusal.
• Known allergy to local anesthetics.
• Coagulopathy or anticoagulant therapy.
• Infection at the site of injection.
• Severe hepatic, renal, or cardiac disease.
• Body mass index (BMI) \> 35 kg/m².
• Pregnancy.

Sponsors & Collaborators

• Sohag University: lead
• Cairo University: collaborator

MeSH Terms

Conditions

Pain, Postoperative

Condition Hierarchy (Ancestors)

Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Pain; Neurologic Manifestations; Signs and Symptoms

Study Officials

• Mohamed Mansour, MD

  Professor of Anesthesia, ICU and Pain Management, Faculty of Medicine, Cairo University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Khaled M Hassan mohamed, MD

CONTACT

01153564555; dr.khalid.azab@gmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, OUTCOMES ASSESSOR
• Masking Details: The study is double-blinded. The anesthesiologist performing the block is not involved in intraoperative management or postoperative assessment. Patients, intraoperative care providers, and outcome assessors are blinded to group allocation.
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Anesthesia specialist

Model Details: Participants will be randomly assigned to one of two parallel groups to receive either bilateral erector spinae plane block or bilateral external oblique intercostal plane block.

Study Record Dates

• First Submitted: April 9, 2026
• First Posted: April 16, 2026
• Study Start (Estimated): June 1, 2026
• Primary Completion (Estimated): June 1, 2026
• Study Completion (Estimated): May 1, 2027
• Last Updated: April 16, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share