External Oblique Intercostal Plane Block for Liver Transplantation Donors

NCT05890079 | Completed

• 1 other identifier: anestezi2
• Study Type: interventional
• Target: 64
• Locations: 1 country
• Sites: 1

Brief Summary

Postoperative pain management is one of the important factors to improve rehabilitation and enhance recovery. External oblique intercostal plane block may be used for abdominal wall analgesia to provide effective analgesia for abdominal surgery. The aim of this study is to investigate the postoperative analgesic efficacy of external oblique intercostal plane block and subcostal transversus abdominis plane block in living liver donors. Researchers will compare the external oblique intercostal plane block group with subcostal transversus abdominis plane block to see if the external oblique intercostal plane block is effective for postoperative analgesia in living liver donors.

Conditions

Liver Transplantation; Donor; Postoperative Pain

Outcome Measures

Primary Outcomes (1)

• Morphine consumption

  The amount of morphine required by the patient and given by the device will be recorded for the first 24 hours.

  Postoperative 24 hours

Secondary Outcomes (3)

• Postoperative visual analog scale scores

  Postoperative 24 hours

• Rescue analgesic drug consumption

  postoperative 24 hours

• Incidence of postoperative nausea and vomiting

  postoperative 24 hours

Study Arms (2)

Subcostal transversus abdominis plane block group

ACTIVE COMPARATOR

The patients in subcostal transversus abdominis plane block group will be received subcostal transversus abdominis plane block and patient controlled analgesia with morphine for postoperative analgesia

Other: Subcostal transversus abdominis plane block

External oblique intercostal plane block group

ACTIVE COMPARATOR

The patients in External oblique intercostal plane block group will be received external oblique intercostal plane block and patient controlled analgesia with morphine for postoperative analgesia

Other: External oblique intercostal plane block

Interventions

Subcostal transversus abdominis plane block OTHER

External oblique intercostal plane block will be administered at the end of the surgery and after skin closure.

Subcostal transversus abdominis plane block group

External oblique intercostal plane block OTHER

External oblique intercostal plane block will be administered at the end of the surgery and after skin closure. .

External oblique intercostal plane block group

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age between 18 and 75 years
• Patients with American Society of Anesthesiology (ASA) physical status I-II
• Patients scheduled for a living donor hepatectomy

You may not qualify if:

• Allergy to local anesthetics
• Coagulopathy
• Skin infection at the block area
• Advanced renal failure
• Chronic pain syndromes
• Alcohol or drug abuse
• Psychiatric disorders

Sponsors & Collaborators

• Istinye University: lead

Study Sites (1)

Istinye University Hospital

Istanbul, Turkey (Türkiye)

Location

Related Publications (1)

• Sahin T, Kavakli AS, Eren E, Aydin A, Sahin NK, Tokac M, Dinckan A. Ultrasound-guided external oblique intercostal plane block versus subcostal transversus abdominis plane block for postoperative analgesia in living liver donors: A prospective randomized trial. J Clin Anesth. 2025 Sep;106:111971. doi: 10.1016/j.jclinane.2025.111971. Epub 2025 Aug 19.

  PMID: 40840080 DERIVED

MeSH Terms

Conditions

Pain, Postoperative

Condition Hierarchy (Ancestors)

Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Pain; Neurologic Manifestations; Signs and Symptoms

Study Officials

• Taylan Sahin, M.D.

  Istinye University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 25, 2023
• First Posted: June 6, 2023
• Study Start: May 8, 2023
• Primary Completion: December 14, 2023
• Study Completion: January 17, 2024
• Last Updated: March 19, 2024

Record last verified: 2023-05

Locations

TU (1)