NCT07229170

Brief Summary

This observational retrospective study aims to evaluate changes in taste perception, eating habits, and behavioral aspects in adults treated with GLP-1 receptor agonists for weight loss. Participants include adults aged 18-60 receiving treatment at specialized nutrition centers in Italy. Data are collected from clinical records, dietary questionnaires, and metabolic assessments before and after at least 12 weeks of GLP-1 agonist treatment. The study's primary goal is to understand how these treatments affect food preferences and taste perception. Secondary outcomes include changes in body weight, body composition, gastrointestinal side effects, and treatment adherence. All data are anonymized and collected according to ethical guidelines.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
150

participants targeted

Target at P50-P75 for all trials

Timeline
20mo left

Started Dec 2025

Typical duration for all trials

Geographic Reach
1 country

4 active sites

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress21%
Dec 2025Jan 2028

First Submitted

Initial submission to the registry

November 13, 2025

Completed
1 day until next milestone

First Posted

Study publicly available on registry

November 14, 2025

Completed
17 days until next milestone

Study Start

First participant enrolled

December 1, 2025

Completed
1.1 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 1, 2027

Expected
1 year until next milestone

Study Completion

Last participant's last visit for all outcomes

January 1, 2028

Last Updated

April 28, 2026

Status Verified

April 1, 2026

Enrollment Period

1.1 years

First QC Date

November 13, 2025

Last Update Submit

April 22, 2026

Conditions

Obesity & OverweightTaste AlterationsWeight LossEating Behavior Changes

Keywords

GLP-1 agonistsObesity treatmentWeight lossTaste perceptionEating habitsObservational study

Outcome Measures

Primary Outcomes (1)

  • Change in taste perception and food preferences

    Assessment of patients' taste perception changes and shifts in eating habits using validated questionnaires and behavioral surveys.

    From baseline to 12 weeks after GLP-1 agonist treatment

Secondary Outcomes (3)

  • Change in body weight

    From baseline to 12 weeks after treatment

  • Gastrointestinal side effects

    Throughout the treatment period

  • Treatment adherence

    Throughout the study duration

Study Arms (1)

GLP-1 Agonist Treated Patients

This cohort includes adult patients aged 18-60 who have been treated with GLP-1 receptor agonists such as semaglutide or tirzepatide for weight loss in specialized nutrition centers in Italy. The study collects retrospective data on changes in taste perception, eating habits, body composition, and treatment adherence over a minimum duration of 12 weeks of therapy. No interventional treatments are administered as part of this observational study.

Eligibility Criteria

Age18 Years - 60 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64)
Sampling MethodNon-Probability Sample
Study Population

Adults with obesity receiving GLP-1 agonist treatment at specialized nutrition centers in Italy, assessed retrospectively.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (4)

San Raffaele Open University

Roma, Italy, 00166, Italy

RECRUITING

Department for the Promotion of Human Science and Quality of Life San Raffaele Open University

Rome, 00166, Italy

RECRUITING

San Raffaele Open University

Rome, 00166, Italy

ACTIVE NOT RECRUITING

San Raffaele Open University

Rome, 00166, Italy

RECRUITING

Related Publications (1)

  • Wilding JPH, Batterham RL, Calanna S, Davies M, Van Gaal LF, Lingvay I, McGowan BM, Rosenstock J, Tran MTD, Wadden TA, Wharton S, Yokote K, Zeuthen N, Kushner RF; STEP 1 Study Group. Once-Weekly Semaglutide in Adults with Overweight or Obesity. N Engl J Med. 2021 Mar 18;384(11):989-1002. doi: 10.1056/NEJMoa2032183. Epub 2021 Feb 10.

    PMID: 33567185BACKGROUND

MeSH Terms

Conditions

ObesityOverweightWeight LossFeeding Behavior

Condition Hierarchy (Ancestors)

OvernutritionNutrition DisordersNutritional and Metabolic DiseasesBody WeightSigns and SymptomsPathological Conditions, Signs and SymptomsBody Weight ChangesBehavior, AnimalBehavior

Central Study Contacts

Mauro Lombardo, MD

CONTACT

+393899740197mauro.lombardo@uniroma5.it

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
RETROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Full professor in Human Nutrition

Study Record Dates

First Submitted

November 13, 2025

First Posted

November 14, 2025

Study Start

December 1, 2025

Primary Completion (Estimated)

January 1, 2027

Study Completion (Estimated)

January 1, 2028

Last Updated

April 28, 2026

Record last verified: 2026-04

Locations

IT(4)