NCT07228689

Brief Summary

The aim of this study is to determine if the widely available artificial intelligence platform ChatGPT can accurately identify the abnormalities present on cytology specimens obtained at EUS-FNB of solid mass lesions in the gastrointestinal tract, in comparison with interpretation by cytopathologists as the gold standard.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
200

participants targeted

Target at P75+ for all trials

Timeline
17mo left

Started Nov 2025

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Progress26%
Nov 2025Oct 2027

Study Start

First participant enrolled

November 12, 2025

Completed
1 day until next milestone

First Submitted

Initial submission to the registry

November 13, 2025

Completed
1 day until next milestone

First Posted

Study publicly available on registry

November 14, 2025

Completed
1 year until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2026

Expected
10 months until next milestone

Study Completion

Last participant's last visit for all outcomes

October 1, 2027

Last Updated

November 14, 2025

Status Verified

November 1, 2025

Enrollment Period

1.1 years

First QC Date

November 13, 2025

Last Update Submit

November 13, 2025

Conditions

Keywords

endoscopic ultrasoundsolid mass lesionartificial intelligencefine needle biopsy

Outcome Measures

Primary Outcomes (1)

  • Diagnostic accuracy at rapid onsite evaluation

    The ability of the AI system to correctly interpret cytology images, compared to cytopathologists.

    1 day

Secondary Outcomes (1)

  • Diagnostic accuracy compared to final pathology

    7 days

Study Arms (2)

Interpretation of cytology specimen by cytopathologist onsite

The interpretation of the cytology specimens will be made onsite by the cytopathologist

Diagnostic Test: EUS-guided fine needle biopsy

Interpretation of cytology specimen by artificial intelligence

The interpretation of the cytology specimens will be made onsite by the AI program

Diagnostic Test: EUS-guided fine needle biopsy

Interventions

EUS-guided fine needle biopsy of solid mass lesions in the gastrointestinal tract

Interpretation of cytology specimen by artificial intelligenceInterpretation of cytology specimen by cytopathologist onsite

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

Patients aged 18 years or greater, undergoing EUS-guided fine needle biopsy of solid mass lesions in the gastrointestinal tract.

You may qualify if:

  • Age 18 years old or greater
  • Patients undergoing EUS-guided fine needle biopsy of solid mass lesions in the gastrointestinal tract

You may not qualify if:

  • Age less than 18 years
  • Patients not undergoing sampling of solid mass lesions at EUS
  • Patients with cystic lesions in the gastrointestinal tract

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Orlando Health Digestive Health Institute

Orlando, Florida, 32806, United States

RECRUITING

MeSH Terms

Conditions

Gastrointestinal Neoplasms

Condition Hierarchy (Ancestors)

Digestive System NeoplasmsNeoplasms by SiteNeoplasmsDigestive System DiseasesGastrointestinal Diseases

Study Officials

  • Ji Young Bang, MD MPH

    Orlando Health

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Target Duration
1 Day
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

November 13, 2025

First Posted

November 14, 2025

Study Start

November 12, 2025

Primary Completion (Estimated)

December 1, 2026

Study Completion (Estimated)

October 1, 2027

Last Updated

November 14, 2025

Record last verified: 2025-11

Locations