Induction Agent Choice With Early Mortality and Prognostic Outcomes in Critically Ill Patients
Association of Induction Agent Choice With Early Mortality and Prognostic Outcomes in Critically Ill Patients: A Large-Scale Retrospective Cohort Analysis
1 other identifier
observational
4
1 country
1
Brief Summary
The aim of this retrospective cohort study is to compare the safety and efficacy of induction agents for tracheal intubation in critically ill adult patients.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for all trials
Started Apr 2026
Shorter than P25 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
October 21, 2025
CompletedFirst Posted
Study publicly available on registry
October 29, 2025
CompletedStudy Start
First participant enrolled
April 18, 2026
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 1, 2026
CompletedStudy Completion
Last participant's last visit for all outcomes
July 1, 2026
ExpectedApril 14, 2026
April 1, 2026
1 month
October 21, 2025
April 11, 2026
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Primary Outcome will be all-cause mortality at day 7 following tracheal intubation
mortality at day 7
day 7
Secondary Outcomes (2)
Peri-intubation cardiovascular collapse
perioperatively
Clinical course outcomes
days
Study Arms (4)
propofol
required induction of the following agent in ICU patient
ketamine
required induction of the following agent in ICU patient
ethomidate
required induction of the following agent in ICU patient
midazolam
required induction of the following agent in ICU patient
Interventions
Clinical data documented throughout the course of hospitalization will be retrieved and analyzed.
Eligibility Criteria
ICU admitted, critically ill patients The study population will include critically ill trauma patients aged 18 years and older who were admitted to the surgical intensive care unit
You may qualify if:
- Age ≥ 18 years
- Admission to the surgical ICU for critical care
- Administration of one of the studied induction agents
- Availability of complete clinical data
You may not qualify if:
- Age \< 18 years
- Absence of documented induction agent administration
- Incomplete or missing medical records
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Zeliha Alicikuslead
- University of Floridacollaborator
Study Sites (1)
UF Health Jacksonville (Shands Hospital)
Jacksonville, Florida, 32209, United States
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
TOLGA SARAÇOĞLU, Prof,MD
Florida University Jacksonville
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- RETROSPECTIVE
- Sponsor Type
- OTHER GOV
- Responsible Party
- SPONSOR INVESTIGATOR
- PI Title
- Assoc. prof. dr
Study Record Dates
First Submitted
October 21, 2025
First Posted
October 29, 2025
Study Start
April 18, 2026
Primary Completion
June 1, 2026
Study Completion (Estimated)
July 1, 2026
Last Updated
April 14, 2026
Record last verified: 2026-04
Data Sharing
- IPD Sharing
- Will not share