Carotenoids in the Skin and Immune Aging

NCT07221643 | Recruiting

• 1 other identifier: 80982
• Study Type: observational
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to examine the connection between the level of carotenoids in the skin and a number of immune related health parameters.

Conditions

No Condition; Skin Carotenoids and Immune-aging

Outcome Measures

Primary Outcomes (1)

• Skin carotenoid levels and skin aging features

  We will assess the skin carotenoid levels' correlation with skin aging features, such as wrinkles, fine lines, and age spots.

  one day

Secondary Outcomes (2)

• Skin carotenoid levels and biomarkers of aging

  one day

• Skin carotenoid levels and self-reported perception of health

  2 weeks

Study Arms (2)

Young adult

Participants are 18 to 30 years old.

Older adult

Participants are over 65 years old.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Healthy individuals who are either between 18 to 30 years old or over 65 years old.

You may qualify if:

• Willing and able to provide written informed consent
• Age 18-30 years OR 65 years and older
• Healthy individuals without uncontrolled medical conditions (over the counter inhaled and topical steroids allowed)
• Fiitzpatrick I-VI (all skin types)

You may not qualify if:

• Pregnant or breastfeeding
• uncontrolled medical conditions
• Skin conditions on the upper extremity that would interfere with skin measurements of carotenoid levels such as active atopic dermatitis or psoriasis
• Concurrent use of medications that affect the immune system, within 4 weeks of enrollment (eg. prednisone, biologics, methotrexate, rapamycin, prescription topical steroids, prescription inhaled steroids, others)
• Unable to follow study protocol

Sponsors & Collaborators

• Stanford University: lead

Study Sites (1)

Stanford Health - General Dermatology Clinic

Redwood City, California, 94063, United States

RECRUITING

Central Study Contacts

Xiaochen Zhong, BA

CONTACT

408-816-0111; xczhong@stanford.edu

Po-Han Ho, MD

CONTACT

pohanho@stanford.edu

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor of Dermatology

Study Record Dates

• First Submitted: September 30, 2025
• First Posted: October 28, 2025
• Study Start: October 9, 2025
• Primary Completion: March 1, 2026
• Study Completion: April 1, 2026
• Last Updated: December 15, 2025

Record last verified: 2025-10

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)