Multi-omics Study of Peritoneal Dialysis Effluent to Explore Biomarkers of Peritoneal Fibrosis

NCT07208513 | Not Yet Recruiting

• 1 other identifier: Multi-omics study
• Study Type: observational
• Target: 55
• Locations: 1 country
• Sites: 1

Brief Summary

Biomarkers of peritoneal fibrosis in patients with peritoneal dialysis were investigated by transcriptomics of exfoliated cells and metabolomics of exfoliated cells in peritoneal dialysis

Conditions

Peritoneal Dialysis; Peritoneal Fibrosis

Outcome Measures

Primary Outcomes (1)

• (1) RNA-seq transcriptomics of exfoliated cells; (2) LC-MS metabolomics of permeable supernatant.

  Extract RNA from exfoliated cells in exupine, perform mRNA-seq analysis, collect exudate supernatant at the same time, perform metabolome analysis based on mass spectrometry detection, machine learning analysis of multi-omics data, and explore sensitive biomarkers for predicting peritoneal fibrosis based on the evaluation data of peritoneal samples of some patients.

  October 2024 - September 2026

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Peritoneal dialysis patients, hemodialysis control patients, and normal renal function control patients

You may qualify if:

• Patients on peritoneal dialysis: a. Age 18-75 years; b. Regular abdominal dialysis due to uremia\> 3 months; c. Signed informed consent
• Hemodialysis patients: a. Age 18-75 years; b. Due to regular hemodialysis due to uremia\> 3 months old, allogeneic kidney transplantation is planned; c. Signed informed consent
• Patients with normal renal function: a. Age 18-75 years; b. Proposed elective inguinal hernia repair surgery; c. Signed informed consent.

You may not qualify if:

• Patients on peritoneal dialysis: a. History of peritonitis in the past 3 months; b. History of abdominal tumors with peritoneal metastases
• Hemodialysis patients: a. Previous abdominal dialysis history; b. History of abdominal tumors with peritoneal metastases Patients with normal renal function: a. History of chronic kidney disease; b. History of abdominal tumors with peritoneal metastases

Sponsors & Collaborators

• Shanghai Jiao Tong University School of Medicine: lead

Study Sites (1)

Renji Hospital

Shanghai, Shanghai Municipality, China

Location

Biospecimen

Retention: SAMPLES WITHOUT DNA

RNA extracted from exfoliated cells in the exudate was collected for mRNA-seq analysis, and the exudate supernatant was collected at the same time, metabolome analysis was performed based on mass spectrometry detection, and machine learning analysis was performed on multi-omics data

MeSH Terms

Conditions

Peritoneal Fibrosis

Condition Hierarchy (Ancestors)

Peritoneal Diseases; Digestive System Diseases; Fibrosis; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Central Study Contacts

Na Jiang, doctor

CONTACT

13585579332; jiangjiang198311@163.com

chenhong feng, doctor

CONTACT

15167930075

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: doctor

Study Record Dates

• First Submitted: September 28, 2025
• First Posted: October 6, 2025
• Study Start: October 20, 2025
• Primary Completion (Estimated): September 30, 2026
• Study Completion (Estimated): September 30, 2026
• Last Updated: October 6, 2025

Record last verified: 2025-09

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)