Understand the Association Between Peritoneal Dialysis Status and Gene Polymorphisms of VEGF and KDR

NCT04888065 | Completed

• 1 other identifier: 2018-220
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

Peritoneal dialysis (PD) is an effective and successful way of renal replacement therapy. The initial transport status is related to distribution of blood vessels and micro inflammation state in peritoneum before PD. Vascular endothelial growth factor(VEGF) and its receptor, kinase insert domain containing receptor(KDR) may play important roles on initial transport status. This study include 200 PD patients from Renji Hospital in Shanghai, China. According to the 4h D/P Cr within three months of starting PD therapy, we analyzed the association between the polymorphisms of VEGF and KDR and initial peritoneal transport property.

Conditions

Peritoneal Dialysis

Outcome Measures

Primary Outcomes (1)

• The relationship between VEGF and KDR Gene polymorphisms and initial transport status in peritoneal dialysis

  According to the 4h dialysate over plasma ratio for creatinine （D/P Cr） within three months of starting PD therapy, patients were divided into high transport(H) or high average transport(HA) (H/HA) group and low transport(L) or low average transport(LA) (L/LA) group. Gene polymorphisms of selected VEGF and KDR SNPs were analyzed using extracted blood DNA from these patients. We aimed to investigate the relationship between VEGF and KDR gene polymorphisms and initial peritoneal transport property.

  For each patient, the outcome would be cross sectional measured at the time the patient does first/initial Peritoneal Equilibration Test. The data collection time period of the study is within 3 months.

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Both gender, end stage renal disease on PD treatment

You may qualify if:

• Patients are Han Chinese;
• Patients prepare for dialysis in our center, and start PD within 3 months after abdominal catheterization;
• Patients successfully complete the first peritoneal equilibration test(PET);
• Follow up regularly in our PD center.

You may not qualify if:

• Patients from hemodialysis to peritoneal dialysis;
• Patients who need peritoneal dialysis due to transplant-renal loss;

Sponsors & Collaborators

• RenJi Hospital: lead

Study Sites (1)

Renji Hospital

Shanghai, Shanghai Municipality, 310115, China

Location

Related Publications (1)

• Qian Y, Ding L, Cao L, Yu Z, Shao X, Wang L, Zhang M, Wang Q, Che X, Jiang N, Yan H, Fang W, Jin Y, Huang J, Gu A, Ni Z. Gene polymorphisms of VEGF and KDR are associated with initial fast peritoneal solute transfer rate in peritoneal dialysis. BMC Nephrol. 2022 Nov 14;23(1):365. doi: 10.1186/s12882-022-02975-5.

  PMID: 36376833 DERIVED

Study Officials

• YUE QIAN, MD

  RenJi Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 27, 2021
• First Posted: May 17, 2021
• Study Start: May 10, 2018
• Primary Completion: October 30, 2020
• Study Completion: December 30, 2020
• Last Updated: May 17, 2021

Record last verified: 2021-04

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)