Influence of Low-level Laser Therapy Versus Low-intensity Pulsed Ultrasound on Different Orthodontic Tooth Movements

NCT06026930 | Unknown

• 1 other identifier: 926/91
• Study Type: interventional
• Target: 82
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this prospective clinical project will be to compare the effect of low-level laser therapy versus low intensity pulsed ultrasound on the rate of different orthodontic tooth movements

Conditions

Effect of Low Level Laser Versus Low Intensity Pulsed Ultra Sound on Rate of Different Orthodontic Tooth Movement by Millimeter

Outcome Measures

Primary Outcomes (1)

• Influence of low-level laser therapy versus low-intensity pulsed ultrasound on rate of different orthodontic tooth movements by millimeter

  rate of orthodontic tooth movement by millimeter

  post interventionalal at 6months

Study Arms (14)

Lipus side: canine retraction

EXPERIMENTAL

application of LIPUS with translation of maxillary canine that will be performed on intervention sides according to a standardized protocol

Device: low-level laser therapy

LIPUS side control side

NO INTERVENTION

LIPUS side:canine retraction control side

LLLT side canine retraction

EXPERIMENTAL

translation of maxillary canine that will be performed with LLLT application according to a standardized protocol

Device: low-level laser therapy

LLLT side canine retraction control side

NO INTERVENTION

LLLT side canine retraction control side wihout intervention

LIPUS groupMolar distalization group inrervention side

EXPERIMENTAL

distalization assisted with LIPUS according to a standardized protocol

Device: low-level laser therapy

LIPUS groupMolar distalization group control side

NO INTERVENTION

distalization without LIPUS intervention

LLLT group: distalization intervntion side

EXPERIMENTAL

distalization will be commenced with application of LLLT according to a standardized protocol

Device: low-level laser therapy

LLLT group: distalization control side

NO INTERVENTION

distalization will be commenced without application of LLLT according to a standardized protocol

LIPUS group: leveling and alignment

EXPERIMENTAL

leveling and alignment assisted with LIPUS according to a standardized protocol

Device: low-level laser therapy

LLLT group: leveling and alignment

EXPERIMENTAL

leveling and alignment be commenced with application of LLLT according to a standardized protocol

Device: low-level laser therapy

leveling and alignment without intervention

NO INTERVENTION

leveling and alignment without intervention

LIPUS group: Intrusion

EXPERIMENTAL

intrusion assisted with LIPUS according to a standardized protocol

Device: low-level laser therapy

LLLT group: Intrusion

EXPERIMENTAL

intrusion assisted with application of LLLT according to a standardized protocol

Device: low-level laser therapy

intrusion control group

NO INTERVENTION

intrusion without intervention

Interventions

low-level laser therapy DEVICE

LLLT and LIPUS has been found to speed up OTM by stimulating the RANK/RANKL/OPG system to initiate osteoclast formation.

Also known as: low intensity pulsed ultrasound

LIPUS group: Intrusion; LIPUS group: leveling and alignment; LIPUS groupMolar distalization group inrervention side; LLLT group: Intrusion; LLLT group: distalization intervntion side; LLLT group: leveling and alignment; LLLT side canine retraction; Lipus side: canine retraction

Eligibility Criteria

• Age: 15 Years - 22 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• \- A- leveling and alignment Eligibility criteria
• \. Age ranges from 14 to 17 years. 2. Bilateral Class II molar relationship. 3. Skeletal Class I or mild Class II relationship. 4. Normal or decreased vertical height. 5. No posterior crowding or spaces. 6. Fully erupted maxillary first and second molars. 7. Congenitally missing or extracted third molars. 8. Good oral hygiene. 9. Absence of any periodontal disease and alveolar bone loss. 10. Absence of medications that may inhibit orthodontic movement
• initial bonding appointment; 6. No required management with interproximal stripping, inter-maxillary elastics, open NiTi springs, and removable or extra-oral devices. Canine retraction Eligibility criteria
• Age, 15 to 25 years; Class ii division 1 malocclusion with mild or no crowding; No previous orthodontic treatment; No systemic disease that might have affected bone formation or density, such as osteoporosis, hyperparathyroidism, or vitamin d deficiency; Adequate oral hygiene; Probing depth values not exceeding 3 mm across the Entire dentition; Adequate thickness of the attached gingiva (1-2 mm); No radiographic evidence of bone loss

You may not qualify if:

• \- Patients who required surgery to correct skeletal discrepancies. Patients with congenital dentoskeletal disorders. Missed or mutilated teeth in maxillary arch. Patients with poor oral hygiene and/or periodontally compromised patients Severe dental crowding that necessitates an extraction approach 2. Abnormal anteroposterior and vertical relationships; 3. Patients with cleft lip and palate, anomalies, and syndromes; 4. Previous orthodontic 5. Treatment; 6. Regular medications intake that could interfere with otm. -

Sponsors & Collaborators

• Al-Azhar University: lead

Study Sites (1)

AlAzhar university

Cairo, Egypt

Location

Related Publications (3)

• Maurya RK, Singh H, Kapoor P, Jain U, Mitra R. Effects of low-level laser and low-intensity pulsed ultrasound therapy on treatment duration and pain perception. J Clin Orthod. 2019 Mar;53(3):154-162. No abstract available.

  PMID: 31009384 RESULT

• El-Bialy T, Farouk K, Carlyle TD, Wiltshire W, Drummond R, Dumore T, Knowlton K, Tompson B. Effect of Low Intensity Pulsed Ultrasound (LIPUS) on Tooth Movement and Root Resorption: A Prospective Multi-Center Randomized Controlled Trial. J Clin Med. 2020 Mar 16;9(3):804. doi: 10.3390/jcm9030804.

  PMID: 32188053 RESULT

• Qamruddin I, Alam MK, Mahroof V, Karim M, Fida M, Khamis MF, Husein A. Biostimulatory Effects of Low-Intensity Pulsed Ultrasound on Rate of Orthodontic Tooth Movement and Associated Pain, Applied at 3-Week Intervals: A Split-Mouth Study. Pain Res Manag. 2021 May 5;2021:6624723. doi: 10.1155/2021/6624723. eCollection 2021.

  PMID: 34035871 RESULT

MeSH Terms

Interventions

Low-Level Light Therapy

Intervention Hierarchy (Ancestors)

Laser Therapy; Therapeutics; Phototherapy

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: FACTORIAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: August 19, 2023
• First Posted: September 7, 2023
• Study Start: September 1, 2023
• Primary Completion: March 1, 2024
• Study Completion: April 1, 2024
• Last Updated: September 7, 2023

Record last verified: 2023-09

Data Sharing

• IPD Sharing: Will share

Locations

EG (1)