Sarcopenia, Metabolic Diseases, and Integrated Aging Longitudinal Evaluation (SMILE)

NCT07205510 | Recruiting

• 1 other identifier: LY2025-239-A
• Study Type: observational
• Target: 10,000
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to establish an ambispective cohort platform centered on the pathological axis of "sarcopenia-metabolic disorders-aging progression", integrating multimodal data including demographic characteristics, lifestyle factors, clinical phenotypes, laboratory tests, medical imaging, and biospecimens. Namely 'Sarcopenia, Metabolic Diseases, and Integrated Aging Longitudinal Evaluation (SMILE)'.

Conditions

Sarcopenia; Metabolic Diseases; All-cause Mortality; Aging; Cardiometabolic Diseases

Keywords

Sarcopenia; Metabolic Diseases; Aging; All-cause mortality; Cardiometabolic Diseases

Outcome Measures

Primary Outcomes (1)

• all-cause mortality

  Collect information on all-cause mortality of patients through hospital medical records, telephone follow-ups, outpatient follow-ups, etc., in order to assess the combined effects and underlying mechanisms of sarcopenia, metabolic diseases, and aging on all-cause mortality.

  From enrollment to the 5-year and 10-year follow-up visit.

Secondary Outcomes (2)

• cause-specific mortality

  At 5 and 10 years from the baseline visit.

• Major adverse cardiovascular events

  At 5 and 10 years from the baseline visit.

Interventions

nothing OTHER

This is an observational study.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients visiting the Geriatrics Department of Renji Hospital affiliated with Shanghai Jiao Tong University School of Medicine, who were aged 18 years and above.

You may qualify if:

• Adults aged 18 and over

You may not qualify if:

• Does not cooperate in signing the informed consent form;
• Does not possess legal capacity;
• In a state of loss of consciousness;
• Suffering from severe mental illness, unable to communicate normally;

Sponsors & Collaborators

• RenJi Hospital: lead

Study Sites (1)

Department of Geriatrics, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.

Shanghai, China

RECRUITING

Biospecimen

Retention: SAMPLES WITH DNA

Serum, whole blood, urine, and fecal specimens

MeSH Terms

Conditions

Sarcopenia; Metabolic Diseases

Condition Hierarchy (Ancestors)

Muscular Atrophy; Neuromuscular Manifestations; Neurologic Manifestations; Nervous System Diseases; Atrophy; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms; Signs and Symptoms; Nutritional and Metabolic Diseases

Central Study Contacts

融 黄, Ph.D

CONTACT

+862168383816; 11084@renji.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: OTHER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 28, 2025
• First Posted: October 3, 2025
• Study Start: December 1, 2020
• Primary Completion (Estimated): December 31, 2040
• Study Completion (Estimated): December 31, 2040
• Last Updated: October 3, 2025

Record last verified: 2025-09

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, CSR

Locations

CN (1)