Relationship Between Liver Cancer and Sarcopenia

NCT05339919 | Unknown

• 1 other identifier: sarcopenia
• Study Type: observational
• Target: 1,200
• Locations: 1 country
• Sites: 1

Brief Summary

By tracking the short-term and long-term results of patients after hepatectomy, the difference of short-term results between patients with sarcopenia and patients without sarcopenia was analyzed, and the correlation between sarcopenia and short-term and long-term results of patients after hepatectomy was explored, so as to improve people's awareness of sarcopenia and pay attention to its prevention and treatment.

Conditions

Liver Cancer; Sarcopenia

Keywords

Sarcopenia; Liver cancer; Hepatectomy; Short-term outcomes; Long-term outcomes

Outcome Measures

Primary Outcomes (2)

• Short-term postoperative results

  Postoperative complications；90 days readmission rate

  3 months

• Long-term results after operation

  Overall survival; Disease free survival

  10 years

Secondary Outcomes (2)

• Postoperative hospitalization time

  2 months

• Hospitalization expenses

  2 months

Interventions

gait speed; ct scan;grip strength and chair stand test DIAGNOSTIC_TEST

The chair stand test was administered, and the time required for the patient to stand five times from a sitting position without using the arms was measured. CT scan was to scan the patient's third lumbar level. For the gait speed test, the time that patients spent walking 8 meters on a flat indoor floor at usual walking speed was measured.Grip strength test:the dominant hand and the nondominant hand were measured twice intermittently (kg), and the average value of 4 values was obtained.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with preoperative clinical diagnosis of liver cancer admitted to the hepatobiliary surgery department and received standard tests and questionnaires.

You may qualify if:

• Patients with preoperative clinical diagnosis of liver cancer
• No cancer other than liver cancer has been diagnosed
• Age ≥18 years

You may not qualify if:

• Patients who could not complete the standard tests and questionnaires
• Patients who did not accept liver resection after evaluation of treatment plan
• Patients who had other concomitant preoperative causes of muscle weakness (injury, fracture, stroke, etc.)
• Patients who missing CT data or CT scan did not reach the level of the third lumbar vertebra (L3)

Sponsors & Collaborators

• First Affiliated Hospital of Wenzhou Medical University: lead
• Qilu Hospital of Shandong University: collaborator
• The Second Hospital of Shandong University: collaborator

Study Sites (1)

Gang Chen

Wenzhou, Zhejiang, 325000, China

Location

Biospecimen

Retention: SAMPLES WITH DNA

night soil；whole blood；Tissue specimen

MeSH Terms

Conditions

Liver Neoplasms; Sarcopenia

Interventions

Walking Speed

Condition Hierarchy (Ancestors)

Digestive System Neoplasms; Neoplasms by Site; Neoplasms; Digestive System Diseases; Liver Diseases; Muscular Atrophy; Neuromuscular Manifestations; Neurologic Manifestations; Nervous System Diseases; Atrophy; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms; Signs and Symptoms

Intervention Hierarchy (Ancestors)

Gait; Physical Examination; Diagnostic Techniques and Procedures; Diagnosis; Walking; Locomotion; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Gang Chen, M.D.

  First Affiliated Hospital of Wenzhou Medical University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Target Duration: 10 Years
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Clinical Professor, Principal Investigator

Study Record Dates

• First Submitted: April 9, 2022
• First Posted: April 21, 2022
• Study Start: May 1, 2020
• Primary Completion: August 11, 2021
• Study Completion: August 28, 2025
• Last Updated: June 15, 2022

Record last verified: 2022-06

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)