Early Pregnancy Ultrasound Parameters Including Corpus Luteum Doppler in Prediction of First Trimester Pregnancy Outcome in Spontaneous Pregnancies.

NCT07204028 | Completed

• 1 other identifier: Corpus luteum Doppler
• Study Type: observational
• Target: 120
• Locations: 1 country
• Sites: 1

Brief Summary

The synthesis of progesterone by corpus luteum is extremely important for the maintenance of normal pregnancy in the first seven weeks. Similarly, the production of progesterone by the placental syncytiotrophoblast increases progressively during the first weeks of gestation, so that in eight and a half weeks the placenta and corpus luteum contribute in equal amounts of progesterone. However, from the eighth week, the placental contribution is sufficient to maintain gestation. Angiogenesis in the corpus luteum occurs under physiologic circumstances in each menstrual cycle and functionally is very important for maintenance of early pregnancy. This role implies a potential correlation between abnormal function of corpus luteum and possible abnormal pregnancy including abortion. Using color Doppler sonography, it was feasible to distinguish the ovary containing an active corpus luteum from the inactive ovary. The technique is simple to use, and the results are displayed obviously.

Conditions

Fetal Conditions

Outcome Measures

Primary Outcomes (1)

• New predictors of first trimester pregnancy outcome

  Evaluation of corpus luteum Doppler as predictor of first trimester outcome.

  6 months

Eligibility Criteria

• Age: Up to 40 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Pregnant female aged less than 40 years at 6-12 weeks.

You may qualify if:

• The age of women in the studied population was up to 40 years.
• Live singleton pregnancy with gestational age 6-9 gestational weeks.
• Patients with threatened miscarriage were included.

You may not qualify if:

• Ectopic pregnancy.
• Multiple pregnancies.
• Vesicular mole.
• Miscarriage in first visit.
• Fetal anomaly.
• Known uterine anomalies.
• Significant pre-pregnancy maternal diseases (e.g., hypertension - diabetes mellitus-systemic lupus) or known thrombophilia (e.g., antiphospholipid syndrome).

Sponsors & Collaborators

• Cairo University: lead

Study Sites (1)

Faculty of Medicine, Cairo University

Giza, Cairo Governorate, 4240310, Egypt

Location

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant professor at obstetrics and gynecology department

Study Record Dates

• First Submitted: September 24, 2025
• First Posted: October 2, 2025
• Study Start: January 1, 2025
• Primary Completion: July 1, 2025
• Study Completion: July 21, 2025
• Last Updated: March 2, 2026

Record last verified: 2025-09

Locations

EG (1)