Assessment of Mean Fetal Kidney Length as a Reliable Parameter for Accurate Estimation of Gestational Age in Late 2nd and 3rd Trimesters

NCT07188324 | Completed

• 1 other identifier: Fetal kidney length by 2D us
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

Accurate GA estimation is necessary when early termination of pregnancy is necessary as soon as the fetus becomes mature e.g. cases of pre-eclampsia, chronic renal disease, severe intrauterine growth retardation (IUGR), diabetes and placenta praevia centralis. Accurate GA estimation is also necessary where certain tests need to be performed for example amniotic fluid and serum assays, chorionic villus sampling and to plan fetal therapies. (Gupta DP et al., 2013)

Conditions

Fetal Conditions

Keywords

Fetal kidney - length-gestational age -2D- ultrasound

Outcome Measures

Primary Outcomes (1)

• Accuracy of estimation of mean fetal kidney length in comparison with other parameters

  Estimation of the gestational age (GA) in weeks by measurement of mean fetal kidney length (MFKL)in mm and detect its accuracy in correlation with gestational age derived from other traditional fetal parameters (BPD, HC, AC\& FL) in mm and actual gestational age derived from first day of last menstrual period.

  18months

Eligibility Criteria

• Sex: female
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Healthy pregnant women at their late second and third trimester by reliable LMP who will meet the inclusion criteria, attend the fetal medicine Unit at Cairo University Hospital and consent to participate in this study.

You may qualify if:

• All healthy women with viable normal singleton pregnancies in their late second and third trimesters (24 weeks - 40 weeks) calculated from their last menstrual period.
• Women who will sure of the dates of their last menstrual period (1st day) and/or those with first obstetrics dating using crown rump length (CRL). 3- Women with regular menstrual cycle in last three months before their last menstrual period.

You may not qualify if:

• Women with high-risk pregnancies such as preeclampsia, diabetes, hypertension, polyhydramnios.
• ❖ Maternal:
• Multiple pregnancies.
• Gross maternal obesity.
• ❖ Fetal:
• Fetus with congenital anomalies especially renal anomalies.
• Fetuses with abnormal renal morphology (a genesis, hypoplasia, cysts, nephromegaly, polycystic kidney, hydronephrosis, etc.…
• Fetuses with renal pelvic dilatation of 5 mm or greater, obscured adrenal and renal border.
• Fetus with growth abnormalities (intrauterine growth retardation or macrosomia).

Sponsors & Collaborators

• Cairo University: lead

Study Sites (1)

Faculty of Medicine, Cairo University

Giza, Cairo Governorate, 4240310, Egypt

Location

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant professor of Obstetrics and Gynecology faculty of medicine

Study Record Dates

• First Submitted: September 12, 2025
• First Posted: September 23, 2025
• Study Start: July 21, 2024
• Primary Completion: January 21, 2026
• Study Completion: February 1, 2026
• Last Updated: March 2, 2026

Record last verified: 2026-02

Locations

EG (1)