Effect of Neurodynamic Mobilization in Patients With Lumbar Disc Herniation

NCT07203560 | Completed

• 1 other identifier: ADU-FTR-GG-01
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

The objective of this randomized controlled trial was to investigate the effects of neurodynamic mobilization on pain intensity, normal joint motion, neurodynamics, functional level, and disability in patients with lumbar disc herniation.

Conditions

Lumbar Disc Herniation; Low Back Pain

Keywords

low back pain; sciatica; Disability Evaluation; Musculoskeletal Manipulations

Outcome Measures

Primary Outcomes (1)

• Pain Intensity

  Patients' rest and activity pain levels was assessed via a visual analog scale (VAS). Participants were asked to mark the intensity of pain they felt on a 10-centimeter (cm) horizontal line (0 indicates no pain, 10 indicates intolerable pain). The point marked on the line was measured with a ruler and the VAS value was recorded in cm

  Pain was assessed at baseline (before treatment) and at the end of 4 weeks of treatment (post-treatment)

Secondary Outcomes (3)

• ROM

  Rom was assessed at baseline (before treatment) and at the end of 4 weeks of treatment (post-treatment).

• Neurodynamic Mobility - Slump Test

  These were assessed at baseline (before treatment) and at the end of 4 weeks of treatment (post-treatment).

• Neurodynamic Mobility - Sit and Reach Test

  Baseline (before treatment) and at the end of 4 weeks of treatment (post-treatment)

Study Arms (2)

Neurodynamic Mobilization + Conventional Therapy (Experimental Group)

EXPERIMENTAL

Participants received the conventional physiotherapy program plus neurodynamic mobilization administered by a physical therapist. Treatment was given 5 days a week for 4 weeks, for a total of 20 sessions.

Other: Neurodynamic Mobilization; Other: Conventional Physiotherapy

Conventional Therapy (Control Group)

ACTIVE COMPARATOR

Individuals in control group received hot therapy (Hotpack, 20 minutes), Conventional Tens (60 Hz, 60 msec, 20 minutes) and Therapeutic Ultrasound (1.5 w/cm2, 10 minutes). Patients were given an exercise program to do at home and the treatment was given 5 days a week for 4 weeks, for a total of 20 sessions, to all patients in the study.

Other: Conventional Physiotherapy

Interventions

Neurodynamic Mobilization OTHER

In the experimental group, neurodynamic mobilization was applied in addition to the conventional physiotherapy program. For the neurodynamic mobilization tibial nerve neural mobilization was performed. For neural mobilization of the tibial nerve, the patient was placed in the side-lying position with the hip in 90° flexion, knee flexion and ankle dorsi flexion. In this position, the ankle and hip positions were maintained, and knee extension was performed. When the symptoms were at a level that would not disturb the patient, it was held for 5 seconds, and knee flexion was performed by plantar flexion of the ankle. This practice was performed twice a week with 10 repetitions by a physiotherapist. The same neurodynamic mobilization exercise was recommended to the patients in the neuromobilization group as a home program with 10 repetitions twice a day.

Neurodynamic Mobilization + Conventional Therapy (Experimental Group)

Conventional Physiotherapy OTHER

All participants received hot pack therapy (20 minutes), conventional TENS (60 Hz, 60 msec, 20 minutes), therapeutic ultrasound (1.5 W/cm², 10 minutes), and a prescribed home exercise program, delivered 5 days per week for 4 weeks (20 sessions in total).

Conventional Therapy (Control Group); Neurodynamic Mobilization + Conventional Therapy (Experimental Group)

Eligibility Criteria

• Age: 20 Years - 60 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Age between 20 and 60 years
• Diagnosed with lumbar disc herniation at one or more of the L3-L4, L4-L5
• L5-S1 levels with prolapsed, protruding, or extruding disc confirmed by MRI
• Presence of low back pain for at least 6 weeks.

You may not qualify if:

• Spinal stenosis
• Previous lumbar surgery or medical treatment for disc herniation
• Pregnancy
• Severe osteoporosis
• Diabetes mellitus
• Severe neurological deficit

Sponsors & Collaborators

• Aydin Adnan Menderes University: lead

Study Sites (1)

Gazi University Department of Physical Therapy and Rehabilitation

Ankara, Çankaya, 06690, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Intervertebral Disc Displacement; Low Back Pain; Sciatica

Condition Hierarchy (Ancestors)

Spinal Diseases; Bone Diseases; Musculoskeletal Diseases; Hernia; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms; Back Pain; Pain; Neurologic Manifestations; Signs and Symptoms; Sciatic Neuropathy; Mononeuropathies; Peripheral Nervous System Diseases; Neuromuscular Diseases; Nervous System Diseases; Neuralgia

Study Officials

• Gurkan Gunaydin

  Aydin Adnan Menderes University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Model Details: Two-arm, parallel-group randomized controlled trial. Control group received a conventional physiotherapy program; intervention group received the same program plus neurodynamic mobilization. Treatments were delivered over 4 consecutive weeks. Outcomes included pain, ROM, neurodynamic mobility, functional status and disability.

Study Record Dates

• First Submitted: September 17, 2025
• First Posted: October 2, 2025
• Study Start: June 4, 2018
• Primary Completion: May 10, 2019
• Study Completion: May 10, 2019
• Last Updated: October 2, 2025

Record last verified: 2025-09

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)