NCT07201480

Brief Summary

The goal of this experimental study is to investigate the transdiagnostic role of death anxiety in depression and anxiety symptoms in participants from the general population. The main questions it aims to answer are:

  1. 1.Does the mortality salience task induce death anxiety?
  2. 2.Does the experimental group present an increase in depression and anxiety symptoms following the mortality salience task?
  3. 3."Please briefly describe the emotions that the thought of your own death arouses in you."
  4. 4."Jot down, as specifically as you can, what you think will happen to you physically as you die and once you are physically dead."
  5. 5."Please briefly describe the emotions that the thought of dental pain arouses in you."
  6. 6."Jot down, as specifically as you can, what you think happens to you physically as you experience dental pain and once you have physically experienced dental pain."

Trial Health

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Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
128

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started Mar 2025

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

March 1, 2025

Completed
3 months until next milestone

First Submitted

Initial submission to the registry

June 12, 2025

Completed
4 months until next milestone

First Posted

Study publicly available on registry

October 1, 2025

Completed
3 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 30, 2025

Completed
2 days until next milestone

Study Completion

Last participant's last visit for all outcomes

January 1, 2026

Completed
Last Updated

October 1, 2025

Status Verified

September 1, 2025

Enrollment Period

10 months

First QC Date

June 12, 2025

Last Update Submit

September 23, 2025

Conditions

Keywords

death anxietydepressionanxietytransdiagnostic

Outcome Measures

Primary Outcomes (1)

  • Collet-Lester Fear of Death Scale - Revised (CLFD-R)

    The Revised version of the Collet-Lester Fear of Death Scale (CLFD-R) is a validated self-report instrument assessing fear and anxiety in regards to death and dying. The scale is comprised of 32 items that are answered from 1 (not at all) to 5 (very much) Possible scores range from 32 to 160. Higher scores indicate worse death anxiety.

    Baseline (Day 1), After the experimental task (Day 14)

Secondary Outcomes (3)

  • The Generalized Anxiety Disorder - 7

    Baseline (Day 1), After the experimental task (Day 14)

  • Patient Health Questionnaire - 9

    Baseline (Day 1), After the experimental task (Day 14)

  • State and Trait Anxiety Inventory - State subscale

    Baseline (Day 1), After the experimental task (Day 14)

Study Arms (2)

Mortality Primed

EXPERIMENTAL

Participants in this arm will be instructed to answer two questions that are meant to bring to awareness thoughts about their mortality: "Please briefly describe the emotions that the thought of your death arouses in you." and "Jot down, as specifically as you can, what you think will happen to you physically as you die and once you are physically dead."

Behavioral: Mortality Salience Prompts

Dental Pain Primed

PLACEBO COMPARATOR

Participants in this arm will be instructed to answer two questions that may bring to mind thoughts and memories of dental pain: "Please briefly describe the emotions that the thought of dental pain arouses in you." and "Jot down, as specifically as you can, what you think happens to you physically as you experience dental pain and once you have physically experienced dental pain."

Behavioral: Dental Pain Prompts

Interventions

This intervention implies giving two prompts to participants, in a written format, while asking them to write out answers to the given prompts. The first prompt is: "Please briefly describe the emotions that the thought of your death arouses in you." The second prompt is "Jot down, as specifically as you can, what you think will happen to you physically as you die and once you are physically dead."

Mortality Primed

This intervention implies giving two prompts to participants, and requesting that participants write out their answers to these prompts. The first prompt is: "Please briefly describe the emotions that the thought of dental pain arouses in you." The second prompt is: "Jot down, as specifically as you can, what you think happens to you physically as you experience dental pain and once you have physically experienced dental pain."

Dental Pain Primed

Eligibility Criteria

Age18 Years - 65 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Age over 18 years.
  • Living in Cluj-Napoca (or otherwise willing and able to participate in the lab task)

You may not qualify if:

  • Personality disorder diagnosis
  • Psychotic disorder diagnosis
  • Suicidal ideation

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Babes Bolyai University

Cluj-Napoca, Romania

RECRUITING

MeSH Terms

Conditions

NecrophobiaDepressionAnxiety Disorders

Condition Hierarchy (Ancestors)

Behavioral SymptomsBehaviorMental Disorders

Central Study Contacts

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
PARTICIPANT
Purpose
BASIC SCIENCE
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
PhD

Study Record Dates

First Submitted

June 12, 2025

First Posted

October 1, 2025

Study Start

March 1, 2025

Primary Completion

December 30, 2025

Study Completion

January 1, 2026

Last Updated

October 1, 2025

Record last verified: 2025-09

Data Sharing

IPD Sharing
Will share

Will share IPD used in the results of the publication, upon request.

Shared Documents
STUDY PROTOCOL, SAP
Time Frame
The IPD may be shared after publication upon request, with no end date.

Locations