NCT07195968|Enrolling By InvitationFDA DrugFDA Device
Comparative Analysis of NTG-Pd/Pa and Saline-Pd/Pa (CANS)
A Prospective, Multicenter Study: Comparative Analysis of NTG-Pd/Pa and Saline-Pd/Pa
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Sponsor study identifier
observational
50
1 country
3
Study Start
September 17, 2025
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Primary Completion
May 31, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
December 31, 2029
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
The goal of this observational study is to compare the value of NTG-Pd/Pa and saline-Pd/Pa in participants with intermediate stenosis of the coronary artery. The main questions it aims to answer are: The numerical difference between NTG-Pd/Pa and saline-Pd/Pa To compare the diagnostic performance of NTG-Pd/Pa and saline-Pd/Pa in predicting the binary result of FFR assessment? Participants will undergo NTG-Pd/Pa, Saline-Pd/Pa, and FFR successively in the target vessel.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
December 31, 2029
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
September 17, 2025
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
September 18, 2025
Actual (reported)September 29, 2025
Actual (reported)May 31, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
December 31, 2029
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Absolute difference between NTG-Pd/Pa and Saline-Pd/Pa value
The absolute difference was calculated as the Saline-Pd/Pa value minus the NTG-Pd/Pa value.
3 minutes
Diagnostic performance of NTG-Pd/Pa and Saline-Pd/Pa
4 minutes
Repeatability of Saline-Pd/Pa
2 minutes
Target vessel failure
3 years
Participants will undergo NTG-Pd/Pa, saline-Pd/Pa, and FFR assessments sequentially. Saline-Pd/Pa will be tested repeatedly during the assessment.
The coronary artery with intermediate stenosis will sequentially undergo NTG-Pd/Pa, saline-Pd/Pa, and FFR assessments. Intracoronary NTG dosage will follow the protocol based on blood pressure.
The coronary artery with intermediate stenosis will sequentially undergo NTG-Pd/Pa, saline-Pd/Pa, and FFR assessments. Ten millilitres of intracoronary saline will be given over five seconds.
Participants referred for coronary angiography with intermediate lesions will be invited to join the registry. Enrollment sites include medical facilities in northern and central Taiwan.
National Taiwan University Hospital Hsin-Chu Hospital
Hsinchu, Select, 30047, Taiwan
Miaoli General Hospital, Ministry of Health and Welfare
Miaoli, 36054, Taiwan
Taichung Veterans General Hospital
Taichung, 407219, Taiwan
Serum
Chien Boon Jong, MD
National Taiwan University Hospital, Hsin-Chu Hospital
First Submitted
September 18, 2025
First Posted
September 29, 2025
Study Start
September 17, 2025
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Primary Completion
May 31, 2027
Web-based Psychological Intervention to Coronary Artery Heart Disease Patients
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Planned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
December 31, 2029
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Last Updated
September 29, 2025
Record last verified: 2025-09
Data cannot be shared publicly because of ethical restrictions. The restrictions apply to the availability of these data, which were used under license for the current study, and so are not publicly available. Data are from the National Taiwan University Hospital Ethics Committee (contact via ntuhrec@ntuh.gov.tw) for researchers who meet the criteria for access to confidential data.
Download the complete ClinicalTrials.gov record imported by Syfrah, including fields not shown in this page. The registry may contain a newer revision.
Source: ClinicalTrials.gov.
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