NCT00172432

Completed

Aminoterminal Propeptide of Type III Procollagen and Severit...

National Taiwan University Hospital Source

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Other study identifiers

Sponsor study identifier

9361700303

Study Type

observational

Reported enrollment (type unavailable)

N/A

Locations

0 countries

Sites

N/A

Timeline

Study Start

Not reported

Date not reported

Primary Completion

Not reported

Date not reported

Study Completion

Not reported

Date not reported

Brief Summary

Background: Myocardial fibrosis is a major component in cardiac remodeling in patients with myocardial infarction or hibernation. However, the association of cardiac fibrosis and coronary artery disease (CAD) in patients without infarction or hibernation is still unclear. In the present study, we analyzed the relationship between serum concentrations of procollagen propeptides and severity of CAD in such patients. Patients and methods: Forty-six patients (32 men and 14 woman; mean age 64 years) with chest pain and normal left ventricular contractility were enrolled into this study. Myocardial infarction was excluded by history and electrocardiograms. All patients received stress thallium-201 single photon emission computed tomography (SPECT) and analysis of the serum levels of the aminoterminal propeptide of type I and III procollagen (PINP and PIIINP).

Registry Overview

Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.

Recruitment status: completed
Reported enrollment (type unavailable): Not reported
Study completion date: Not reported
Date not reported
Listed locations: 0 countries · 0 sites

Trial Relationships

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Study Timeline

Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.

First Submitted
September 12, 2005
Actual (reported)
First Posted
September 15, 2005
Actual (reported)

Last Updated: September 15, 2005
Status Verified: August 2005
Last Update Submitted: September 12, 2005

Conditions

Coronary Artery Disease

Eligibility Criteria

Age50 Years - 75 Years

Sexall

Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

We prospectively studied 46 consecutive patients aged 50 to 75 years (32 men and 14 women; mean age was 64 years) who were referred for chest pain evaluation.

You may not qualify if:

MI was excluded by history and electrocardiograms. Regional wall motion abnormalities and impaired left ventricular contractility (left ventricular ejection fraction \< 50%) were excluded by routine echocardiography.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

National Taiwan University Hospital
Otherlead

MeSH Terms

Conditions

Coronary Artery Disease

Condition Hierarchy (Ancestors)

Coronary DiseaseMyocardial IschemiaHeart DiseasesCardiovascular DiseasesArteriosclerosisArterial Occlusive DiseasesVascular Diseases

Study Officials

Yi-Lwun Ho, MD, PhD
National Taiwan University Hospital
PRINCIPAL INVESTIGATOR

Study Design

Study Type: observational
Observational Model: CASE CONTROL
Time Perspective: PROSPECTIVE
Sponsor Type: OTHER

Study Record Dates

First Submitted

September 12, 2005

First Posted

September 15, 2005

Last Updated

September 15, 2005

Record last verified: 2005-08

Source record

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Source: ClinicalTrials.gov.

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