Testing YAG Laser Iridotomy for Primary Angle-Closure Glaucoma

NCT07195370 | Active Not Recruiting DMC

• 2 other identifiers: feiz-123456IR.MUI.MED.REC.1401.153
• Study Type: interventional
• Target: 150
• Locations: 1 country
• Sites: 1

Brief Summary

This study evaluates the effectiveness and safety of YAG laser peripheral iridotomy performed at two different locations (temporal and inferior) in patients with primary angle-closure glaucoma, a leading cause of blindness worldwide. Patients visiting the glaucoma clinic at Feiz Hospital who are candidates for peripheral iridotomy will participate. In each patient, one eye will receive a temporal iridotomy, and the other eye will receive an inferior iridotomy, with patients unaware of the location used in each eye. The study will measure outcomes such as laser power, intraocular pressure, visual symptoms, and complications over six months to determine which approach is more effective and safer.

Conditions

Glaucoma Eye; Angle Closure Glaucoma

Keywords

Primary Angle-Closure Glaucoma

Outcome Measures

Primary Outcomes (1)

• adverse events

  Surgical and postoperative complications (e.g., bleeding, infection, or changes in intraocular pressure).

  1 day, 1 week, 1month

Study Arms (1)

Description: YAG laser peripheral iridotomy performed in the temporal region of one eye. Arm 2 Title

OTHER

Other: peripheral iridotomy

Interventions

peripheral iridotomy OTHER

This procedure involves using a neodymium-doped yttrium aluminum garnet (YAG) laser to create a small hole in the temporal region of the iris in one eye. It aims to relieve intraocular pressure in patients with primary angle-closure glaucoma by improving the flow of aqueous humor. The procedure is performed under local anesthesia in a clinical setting, with patients unaware of which eye receives this treatment. Outcomes, including laser power, intraocular pressure, visual symptoms, and complications, are monitored over six months.

Description: YAG laser peripheral iridotomy performed in the temporal region of one eye. Arm 2 Title

Eligibility Criteria

• Age: 24 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Adults (typically over 40 years old).
• Ability to provide informed consent.
• Narrow or closed anterior chamber angle (based on gonioscopy).
• Intraocular pressure (IOP) controlled with medication but requiring surgery.
• No previous iridotomy.

You may not qualify if:

• Active eye diseases (e.g., infection or inflammation).
• Advanced cataracts or lens-related issues.
• Severe visual impairment (e.g., less than 20/200 vision).
• Uncontrolled systemic diseases (e.g., diabetes or cardiovascular disease).
• Pregnancy or breastfeeding.
• Previous eye surgery (except for minor procedures).
• Inability to follow-up with scheduled visits.

Sponsors & Collaborators

• Isfahan University of Medical Sciences: lead

Study Sites (1)

Isfahan University of Medical Sciences

Isfahan, Isfahan, 0098, Iran

Location

MeSH Terms

Conditions

Glaucoma, Angle-Closure

Condition Hierarchy (Ancestors)

Glaucoma; Ocular Hypertension; Eye Diseases

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: HEALTH SERVICES RESEARCH
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: IsfahanUMS

Study Record Dates

• First Submitted: August 26, 2025
• First Posted: September 26, 2025
• Study Start: May 1, 2025
• Primary Completion: October 1, 2025
• Study Completion: January 1, 2026
• Last Updated: September 26, 2025

Record last verified: 2025-09

Data Sharing

• IPD Sharing: Will not share

Locations

IR (1)