Relationship Between Diabetes and Periodontitis

NCT07193979 | Completed

• 1 other identifier: 2024/341
• Study Type: observational
• Target: 120
• Locations: 1 country
• Sites: 1

Brief Summary

Diabetes mellitus, one of the major global health problems of the 21st century, is a chronic metabolic disease characterized by dysregulated nutrient metabolism resulting from defects in insulin secretion and action. Patients with diabetes mellitus are more likely to develop chronic periodontitis. A bidirectional relationship between diabetes mellitus and periodontitis has been demonstrated. Dental complications of diabetes mellitus include periodontitis and dental caries. Dental caries, resulting from tooth demineralization, are more prevalent in diabetic individuals than in non-diabetic individuals. For adults, HbA1c levels were defined as \<7% ("good" control), HbA1c levels between 7% and 8% as "inadequate" control, and levels above 8% as "poor" control. In the study conducted by the investigators, patients diagnosed with type 2 diabetes mellitus and those diagnosed with periodontitis were grouped according to HbA1C levels, and the relationship between these levels and the stage/degree of periodontitis and the degree of caries was examined. Although studies on periodontal diseases and dental caries among adults with type 2 diabetes mellitus exist in the literature, no study has, as far as is known that classifies HbA1c levels in patients with controlled and uncontrolled diabetes diagnosed with periodontitis and explains the relationship between these groups and the stage/degree of periodontitis and the degree of caries.

Conditions

Diabetes (DM); Periodontitis

Outcome Measures

Primary Outcomes (4)

• Periodontal Index (PI) Score

  PI will be used to assess periodontal health, scored according to WHO guidelines (Unit of Measure: Millimeters (mm))

  One-time measurement at the beginning of the study

• Clinical Attachment Loss (CAL)

  Clinical attachment loss will be measured at six sites per tooth using a periodontal probe (Unit of Measure: Millimeters (mm))

  One-time measurement at the beginning of the study

• Probing Depth (PD)

  Probing depth will be measured at six sites per tooth using a periodontal probe.(Millimeters (mm))

  One-time measurement at the beginning of the study

• Total DMFT Index Score

  The DMFT index will be calculated by summing the number of decayed (D), missing (M), and filled (F) teeth for each participant, as per WHO guidelines.

  One-time measurement at the beginning of the study

Secondary Outcomes (5)

• Bleeding on Probing (BOP)

  One-time measurement at the beginning of the study

• Gingival Index (GI)

  One-time measurement at the beginning of the study

• Number of Decayed Teeth (D Component of DMFT Index)

  One-time measurement at the beginning of the study

• Number of Missing Teeth (M Component of DMFT Index)

  One-time measurement at the beginning of the study

• Number of Filled Teeth (F Component of DMFT Index)

  One-time measurement at the beginning of the study

Study Arms (3)

Group 1

HgA1c \<7 diabetic patients

Group 2

Diabetic patients with HgA1c 7≤ \<8 in this range

Group 3

HgA1c ≥8 diabetic patients

Eligibility Criteria

• Age: 23 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

This study was conducted among individuals who applied to Afyonkarahisar Health Sciences University Faculty of Dentistry and volunteered to participate in the study.

You may qualify if:

• Age between 20 and 65 years Diagnosed with Type 2 Diabetes Mellitus (T2DM) Diagnosed with periodontitis, according to established clinical criteria

You may not qualify if:

• Diagnosis of Type 1 Diabetes Mellitus Diagnosis of gestational diabetes Presence of physical or mental disorders that may affect participation or evaluation Undergoing chemotherapy or radiotherapy Presence of any systemic disease other than diabetes mellitus Use of systemic antibiotics or other medications in the past 3 months Use of antiparkinsonian, antidepressant, or antipsychotic medications

Sponsors & Collaborators

• Afyonkarahisar Health Sciences University: lead

Study Sites (1)

Afyonkarahisar Health Sciences University Faculty of Dentistry

Afyonkarahisar, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Diabetes Mellitus; Periodontitis

Condition Hierarchy (Ancestors)

Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases; Periodontal Diseases; Mouth Diseases; Stomatognathic Diseases

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: assist. prof.

Study Record Dates

• First Submitted: September 12, 2025
• First Posted: September 26, 2025
• Study Start: November 1, 2024
• Primary Completion: May 1, 2025
• Study Completion: August 1, 2025
• Last Updated: September 26, 2025

Record last verified: 2025-09

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)