Prevalence and Clinical Impact of Airway Opening Pressure in Post-Cardiac Surgery Patients

NCT07189026 | Active Not Recruiting

• 1 other identifier: 2026-4399
• Study Type: interventional
• Target: 196
• Locations: 1 country
• Sites: 1

Brief Summary

Airway opening pressure is a key parameter in assessing respiratory mechanics. Current practice primarily relies on indirect assessments of lung mechanics, but growing evidence suggests that direct airway opening pressure measurement could enhance individualized ventilatory strategies. Significant airway opening pressure suggests incomplete alveolar recruitment at end-expiration, which may contribute to ventilation-perfusion mismatch, increased respiratory effort, and postoperative pulmonary complications such as atelectasis and impaired gas exchange. Determining the prevalence and clinical relevance of significant airway opening pressure in post-cardiac surgery patients could contribute to more personalized respiratory strategies and improve postoperative care.

Conditions

Cardiac Surgery; Mechanical Ventilation After Surgery

Outcome Measures

Primary Outcomes (1)

• Prevalence of significant airway opening pressure

  airway opening pressure ≥ 5 cmH₂O

  up to 1 hour after intensive care admission

Secondary Outcomes (13)

• Airway opening pressure prevalence based on body mass index

  up to 1 hour

• Airway opening pressure prevalence based on cardiopulmonary bypass duration

  up to 1 hour

• Airway opening pressure prevalence based on left ventricular dysfunction

  up to 1 hour

• Airway opening pressure prevalence based on inotropic support

  up to 1 hour

• Airway opening pressure prevalence based on age

  up to 1 hour

Study Arms (1)

Post operative cardiac surgery

OTHER

Diagnostic Test: Airway opening pressure

Interventions

Airway opening pressure DIAGNOSTIC_TEST

Airway opening pressure will be measured within one hour of intensive care unit admission (using a standardized low-flow insufflation maneuver flow 5-6 LPM). The inflection point on the pressure-time or pressure-volume waveform- depending on ventilator model-will define the airway opening pressure.

Post operative cardiac surgery

Eligibility Criteria

• Age: 18 Months+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• Adult (≥18 years)
• Undergoing elective coronary artery bypass grafting (CABG) or valve surgery, or combined procedures with expected postoperative mechanical ventilation

You may not qualify if:

• \- Patient receiving invasive mechanical ventilation prior to surgery

Sponsors & Collaborators

• Laval University: lead

Study Sites (1)

Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval

Québec, Quebec, Canada

Location

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: August 27, 2025
• First Posted: September 23, 2025
• Study Start: June 27, 2025
• Primary Completion (Estimated): December 1, 2026
• Study Completion (Estimated): June 1, 2027
• Last Updated: September 23, 2025

Record last verified: 2025-09

Data Sharing

• IPD Sharing: Will not share

Locations

CA (1)