SWE to Detect Enthesitis in PsA: Relationship With SIRT2 Expression and Disease Activity

NCT07188688 | Not Yet Recruiting

• 1 other identifier: SWE of tendons in PsA
• Study Type: observational
• Target: 57
• Locations: 1 country
• Sites: 1

Brief Summary

1. 1.To assess the diagnostic utility of shear-wave elastography (SWE), gray-scale (GS) ultrasound, and Power Doppler (PD) in detecting Patellar and Achilles tendinopathy in psoriatic patients with and without arthritis.
2. 2.Investigate the relation between SWE, GS ultrasound, and PD finding and SIRT2 expression levels.
3. 3.Evaluate the association of the imaging findings and SIRT2 levels with psoriatic arthritis disease activity score.

Conditions

Shear Wave Elastography

Outcome Measures

Primary Outcomes (1)

• Assessment and comparting the diagnostic utility of shear-wave elastography (SWE) , Gray-scale (GS) ultrasound. and Power Doppler (PD) in detecting tendinopathy in psoriatic patients with and without arthritis.

  Musculoskeletal Ultrasound assessment by LOGIQ P10 from General Electric (GE) Healthcare, a division of General Electric Company

  At baseline (single study visit)

Secondary Outcomes (1)

• Investigate the correlation between SWE, GS ultrasound and PD finding and SIRT2 expression levels and evaluate the correlation of the imaging finding and SIRT2 levels with psoriatic arthritis disease activity score (PASDAS).

  At baseline (single study visit)

Interventions

Musculoskeletal Ultrasound Device DEVICE

Musculoskeletal Ultrasound assessment by LOGIQ P10 from General Electric (GE) Healthcare, each patient will be evaluated by grey scale, power doppler MSUS and Shear Wave Elastography (SWE)

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

57 participants: 19 Psoriatic arthritis patients, 19 Psoriasis-only patients and 19 healthy control.

You may qualify if:

• Patients diagnosed as PsO by a dermatologist according to PASI score.
• Patients diagnosed as PsA by rheumatologist according to CASPAR classification criteria for psoriatic arthritis
• Adult patients of both sexes with an average \> 18 years

You may not qualify if:

• Patients with a history of metabolic disease affecting tendons.
• Patients with history of surgery, injury or trauma of patellar and/or Achilles tendon.
• Patients with other rheumatological diseases.
• Patients below 18.

Sponsors & Collaborators

• Assiut University: lead

Study Sites (1)

Assiut University

Asyut, 71111, Egypt

Location

Related Publications (3)

• Scalcon MRR, Waclawovsky AJ, Schuch FB, Speeckaert MM, Moresco RN. Proteomic biomarkers in psoriatic arthritis. Clin Chim Acta. 2025 May 15;572:120244. doi: 10.1016/j.cca.2025.120244. Epub 2025 Mar 15.

  PMID: 40096904 BACKGROUND

• Saha D, Prakash M, Sinha A, Singh T, Dogra S, Sharma A. Role of Shear-Wave Elastography in Achilles Tendon in Psoriatic Arthritis and Its Correlation with Disease Severity Score, Psoriasis Area and Severity Index. Indian J Radiol Imaging. 2022 Jul 13;32(2):159-165. doi: 10.1055/s-0042-1743116. eCollection 2022 Jun.

  PMID: 35924126 BACKGROUND

• Mifsud T, Gatt A, Micallef-Stafrace K, Chockalingam N, Padhiar N. Elastography in the assessment of the Achilles tendon: a systematic review of measurement properties. J Foot Ankle Res. 2023 Apr 27;16(1):23. doi: 10.1186/s13047-023-00623-1.

  PMID: 37101290 BACKGROUND

Study Officials

• Eman Abbas M Alkady, Professor

  Rheumatology, Rehabilitation and Physical Medicine, Assiut University Hospitals

  PRINCIPAL INVESTIGATOR

• Doaa Kamal M. Abdelhafez, Associate Professor

  Rheumatology, Rehabilitation and Physical Medicine, Assiut University Hospitals

  PRINCIPAL INVESTIGATOR

• Nesreen Ismail Ibrahim, Lecturer

  Rheumatology, Rehabilitation and Physical Medicine, Assiut University Hospitals

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Nada MMN ELSHENAWY, Specialist

CONTACT

+201002973457; nadaaa.mahmoud@med.aun.edu.eg

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Specialist of Rheumatology, Rehabilitation and Physical Medicine , Assiut University Hospitals

Study Record Dates

• First Submitted: September 12, 2025
• First Posted: September 23, 2025
• Study Start: October 1, 2025
• Primary Completion (Estimated): October 1, 2026
• Study Completion (Estimated): November 1, 2026
• Last Updated: September 23, 2025

Record last verified: 2025-09

Locations

EG (1)