Impact of Fluid Resuscitation on Venous Congestion in Cardiac Critically-ill Patients

NCT07183397 | Not Yet Recruiting

• 1 other identifier: 1706/2025
• Study Type: observational
• Target: 250
• Locations: 0 countries
• Sites: N/A

Brief Summary

The objective of this study is to assess how fluid resuscitation, in the context of fluid responsiveness, affects the incidence and progression of systemic venous congestion in critically ill cardiac patients. Additionally, the study aims to evaluate the impact on clinical outcomes, with a particular focus on acute kidney dysfunction. This assessment will utilize the VExUS score in conjunction with comprehensive bedside echocardiographic evaluations.

Conditions

Cardiac and Aortic Surgery; Cardiac Anaesthesia; Venous Congestion; Fluid Resuscitation

Outcome Measures

Primary Outcomes (2)

• Venous congestion

  Venous congestion as assessed by the VExUS score at ICU admission, and on each of the first seven postoperative days.

  7 days

• Acute kidney injury

  Acute kidney injury (AKI), defined through the KDIGO criteria, within seven and twenty-eight days of ICU admission.

  Twenty-eight days

Interventions

VExUS & Cardiac Ultrasound DIAGNOSTIC_TEST

The VExUS system provides a semi-quantitative assessment of systemic venous congestion by integrating ultrasound evaluations of the inferior vena cava diameter, hepatic vein flow, portal pulsatility, and renal venous flow, offering a practical and comprehensive bedside tool

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Cardiac critically ill patients (mainly post cardiac surgery)

You may qualify if:

• Age above 18 years
• Admission to cardiac intensive care unit

Sponsors & Collaborators

• Medical University of Vienna: lead

Biospecimen

Retention: SAMPLES WITHOUT DNA

Blood Samples

MeSH Terms

Conditions

Hyperemia

Condition Hierarchy (Ancestors)

Vascular Diseases; Cardiovascular Diseases

Central Study Contacts

Pedro D Wendel Garcia, Dr. med.

CONTACT

+4369981577596; pedro.wendelgarcia@meduniwien.ac.at

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dr.med.

Study Record Dates

• First Submitted: September 14, 2025
• First Posted: September 19, 2025
• Study Start: September 15, 2025
• Primary Completion (Estimated): September 1, 2027
• Study Completion (Estimated): December 1, 2027
• Last Updated: September 19, 2025

Record last verified: 2025-09