WAMIF: Prospective Study in Young Women Presenting Acute Myocardial Infarction: Cohort Follow up

NCT07181317 | Recruiting

• 1 other identifier: 2025-04
• Study Type: observational
• Target: 314
• Locations: 1 country
• Sites: 1

Brief Summary

The WAMIF study was conducted from 2017 to 2019, including 314 patients in 30 French research centers spread across metropolitan France. It systematically collected the clinical, morphological, and biological characteristics of myocardial infarction cases affecting women under 50 years of age and assessed their short-term (in-hospital) and medium-term (12-month) prognosis. Extending the follow-up beyond 12 months for this first study would provide fundamental data for understanding and improving the care of these patients.

Conditions

Myocardial Infarction, Acute

Outcome Measures

Primary Outcomes (9)

• Death from any cause

  Number of patient who died from any cause since their participation in WAMIF study

  5 to 10 years after the participation in WAMIF study

• Cardiovascular death

  Number of patient who died from cardiovascular cause since their participation in WAMIF study

  5 to 10 years after the participation in WAMIF study

• Stent thrombosis

  Number of patient who had stent thrombosis since their participation in WAMIF study

  5 to 10 years after the participation in WAMIF study

• Stroke

  Number of patient who had stroke since their participation in WAMIF study

  5 to 10 years after the participation in WAMIF study

• Recurrent myocardial infarct

  Number of patient who had recurrent myocardial infarct since their participation in WAMIF study

  5 to 10 years after the participation in WAMIF study

• Emergency revascularization

  Number of patient who had emergency revascularization since their participation in WAMIF study

  5 to 10 years after the participation in WAMIF study

• Major bleeding

  Number of patient who had since major bleeding their participation in WAMIF study

  5 to 10 years after the participation in WAMIF study

• Emergency hospitalization for heart failure

  Number of patient who had emergency hospitalization for heart failure since their participation in WAMIF study

  5 to 10 years after the participation in WAMIF study

• Emergency department visit

  Number of patient who went to emergency department since their participation in WAMIF study

  5 to 10 years after the participation in WAMIF study

Secondary Outcomes (5)

• Stress score

  5 to 10 years after the participation in WAMIF study

• Anxiety score

  5 to 10 years after the participation in WAMIF study

• Depression score

  5 to 10 years after the participation in WAMIF study

• Quality of life score

  5 to 10 years after the participation in WAMIF study

• Quality of life score

  5 to 10 years after the participation in WAMIF study

Study Arms (1)

WAMIF patients

All patients who participated in the WAMIF study (NCT 03073447) and wish to continue follow-up in the present "WAMIF-suivi" study.

Other: Questionnaires; Other: Major events

Interventions

Major events OTHER

Collection of information related to major events occurring since inclusion in the WAMIF study

WAMIF patients

Questionnaires OTHER

Assessment of stress and anxiety and quality of life after myocardial infarct: * Stress score: Perceived Stress Scale-4 (PSS-4) * Anxiety score: Generalized Anxiety Disorder-7 (GAD-7) * Depression score: Patient Health Questionnaire-9 (PHQ-9) * Quality of life scores: European Quality of Life-5 Dimensions (EQ-5D) and 12-Item Short-Form General Health Survey (SF-12)

WAMIF patients

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

314 women who had a myocardial infarction at less than 50 years, included in the WAMIF study conducted from 2017 to 2019 in 30 French research centers.

All patients who participated in the WAMIF study (research registration number with the French Ministry of Health : 2015-A01263-46 / Protocol registration with Clinical Trials NCT03073447) and wish to continue follow-up in the study.

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

• French Cardiology Society: lead

Study Sites (1)

Hôpital de la Pitié Salpétrière

Paris, 75012, France

RECRUITING

MeSH Terms

Conditions

Myocardial Infarction

Interventions

Surveys and Questionnaires

Condition Hierarchy (Ancestors)

Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Vascular Diseases; Infarction; Ischemia; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Necrosis

Intervention Hierarchy (Ancestors)

Data Collection; Epidemiologic Methods; Investigative Techniques; Health Care Evaluation Mechanisms; Quality of Health Care; Health Care Quality, Access, and Evaluation; Public Health; Environment and Public Health

Study Officials

• Stéphane MANZO SILBERMAN, MD

  Hôpital de la Pitié-Salpêtrière, APHP

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Tessa BERGOT, MSc

CONTACT

+33144907033; tessa.bergot@sfcardio.fr

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 8, 2025
• First Posted: September 18, 2025
• Study Start: November 25, 2025
• Primary Completion (Estimated): September 30, 2029
• Study Completion (Estimated): September 30, 2029
• Last Updated: January 12, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)