Neurocognitive Effects of Meal Timing in a One-Meal-a-Day Regimen

NCT07181057 | Completed

• 1 other identifier: ETU-OMAD-2025-01
• Study Type: interventional
• Target: 12
• Locations: 1 country
• Sites: 1

Brief Summary

Objectives: The purpose of this study is to examine how meal timing in a one-meal-a-day (OMAD) regimen influences neurocognitive outcomes. Methods: Twelve cognitively active participants (academics, students, software engineers) will complete three randomized OMAD conditions, consuming a standardized isocaloric meal at 08:00, 12:30, or 18:00. ERPs will be recorded during a computerized Stroop task to evaluate peak amplitudes and latencies under congruent and incongruent conditions. Resting-state EEG will be measured under eyes-open and eyes-closed conditions. Behavioral performance on the Stroop task, including reaction time and accuracy, will also be assessed.

Conditions

Fasting State; Cognitive Abilities

Outcome Measures

Primary Outcomes (2)

• Positive Peak Amplitude of Event-Related Potentials During Stroop - Congruent Trials

  Maximum voltage deflection (µV) within 250-450 ms after stimulus onset at CP1, CP2, Pz, P3, O1, and O2 electrodes, recorded during congruent Stroop trials using a 32-channel EEG system.

  Day 1 Morning session (09:30-11:00, pre-meal) and Day 1 Afternoon session (14:30-16:00, ~6 hours post-meal). Each participant completes three separate test days (morning, midday, evening feeding), ≥48 hours apart.

• Latency of Positive Peak of Event-Related Potentials During Stroop - Congruent Trials

  Time point (ms) of maximum positive deflection within 250-450 ms after stimulus onset at CP1, CP2, Pz, P3, O1, and O2 electrodes.

  Day 1 Morning session (09:30-11:00, pre-meal) and Day 1 Afternoon session (14:30-16:00, ~6 hours post-meal). Each participant completes three separate test days (morning, midday, evening feeding), ≥48 hours apart.

Secondary Outcomes (1)

• Resting-State EEG Absolute Power (Eyes-Open and Eyes-Closed)

  Day 1 Morning session (09:30-11:00, pre-meal) and Day 1 Afternoon session (14:30-16:00, ~6 hours post-meal). Each participant completes three separate test days (morning, midday, evening feeding), ≥48 hours apart.

Study Arms (1)

Single Group (Crossover)

EXPERIMENTAL

Arm Title: Morning Meal (08:00) Arm Type: Experimental Intervention: Other: One-meal-a-day (OMAD) Arm Description: Participants consume a single standardized isocaloric meal at 08:00. Neurocognitive outcomes (ERP, resting-state EEG, Stroop performance) are assessed during morning (before meal) and afternoon (approximately 6 hours post-meal) sessions. Arm Title: Midday Meal (12:30) Arm Type: Experimental Intervention: Other: One-meal-a-day (OMAD) Arm Description: Participants consume a single standardized isocaloric meal at 12:30. Neurocognitive outcomes (ERP, resting-state EEG, Stroop performance) are assessed during morning (before meal) and afternoon (approximately 6 hours post-meal) sessions. Arm Title: Evening Meal (18:00) Arm Type: Experimental Intervention: Other: One-meal-a-day (OMAD) Arm Description: Participants consume a single standardized isocaloric meal at 18:00. Neurocognitive outcomes (ERP, resting-state EEG, Stroop performance) are assessed during morning (before mea

Other: one-meal-a-day (OMAD)

Interventions

one-meal-a-day (OMAD) OTHER

Arm Title: Morning Meal (08:00) Intervention: Other: One-meal-a-day (OMAD) Description: Participants consume a single isocaloric meal at 08:00. Arm Title: Midday Meal (12:30) Intervention: Other: One-meal-a-day (OMAD) Description: Participants consume a single isocaloric meal at 12:30. Arm Title: Evening Meal (18:00) Intervention: Other: One-meal-a-day (OMAD) Description: Participants consume a single isocaloric meal at 18:00.

Single Group (Crossover)

Eligibility Criteria

• Age: 20 Years - 40 Years
• Gender Eligibility Details: To minimize hormone-related variability in electroencephalography and event-related potential measures in this pilot crossover study, enrollment is limited to males.
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Male, 20 to 45 years of age
• Right-handed
• Normal or corrected-to-normal vision
• Cognitively active individuals (academic staff, graduate students, or software/algorithm engineers)
• Regular sleep-wake schedule during the week preceding the experiment
• Ability to abstain from caffeine, alcohol, or psychoactive substances for at least 24 hours prior to each test session
• Body mass index between 18.5 and 30 kg/m²

You may not qualify if:

• History of neurological, psychiatric, metabolic, or sleep disorders
• Current use of medications that affect the central nervous system
• Shift work or irregular sleep patterns (verified by sleep diary)
• Prior experience with one-meal-a-day dietary routines
• Body mass index below 18.5 or above 30 kg/m²

Sponsors & Collaborators

• Erzurum Technical University: lead

Study Sites (1)

Erzurum Technical University Sport Sciences Faculty

Erzurum, Erzurum, 25240, Turkey (Türkiye)

Location

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: OTHER
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor of Exercise Physiology

Study Record Dates

• First Submitted: August 25, 2025
• First Posted: September 18, 2025
• Study Start: March 1, 2025
• Primary Completion: May 1, 2025
• Study Completion: May 15, 2025
• Last Updated: September 18, 2025

Record last verified: 2025-08

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)