Telerehab Exerbrain: Bridging Physical and Cognitive Therapy in Stroke

NCT07446062 | Not Yet Recruiting

• 1 other identifier: N42A680192
• Study Type: interventional
• Target: 52
• Locations: 0 countries
• Sites: N/A

Brief Summary

The goal of this clinical trial is to learn if a web-based exercise and cognitive training (physical-cognitive) program works to improve movements and brain function in adults with long-term stroke. It will also learn whether the program is safe and enjoyable. The main questions it aims to answer are: Does the program improve walking, balance, strength, and reduce fall risk? Does the program improve cognitive skills such as memory, attention, and problem-solving? Researchers will compare the online exercise-and-cognitive training program to usual care to see if the program leads to greater improvements. Participants will:

• Be randomly assigned to either the online training group or the usual care group
• If in the training group, complete the home-based program for 12 weeks.
• Take part in physical and cognitive tests before and after the program

Conditions

Stroke; Tele-rehabilitation; Exercise; Motor Abilities; Cognitive Abilities

Outcome Measures

Primary Outcomes (3)

• Executive function

  Trail Making Test (TMT) part B-A will be evaluated at baseline and 3 months.

  3 months

• Fall risk

  Fall risk will be assessed using the Timed Up and Go (TUG) test at baseline and 3 months. The time taken to complete TUG will be recorded in Sec.

  3 months

• Gait speed

  10-Meter Walk test (10MWT) will be used to assessed gait speed at baseline and 3 months.

  3 months.

Secondary Outcomes (7)

• Global cognitive function

  3 months

• Attention

  3 months

• Motor function

  3 months

• Balance

  3 months

• Muscle strength

  3 months

Study Arms (2)

Web-Based Physical-Cognitive Telerehabilitation Exergaming

EXPERIMENTAL

Physical-cognitive exergame via web-based platform at home setting for 60 min/session, 3 sessions/week for 12 weeks.

Behavioral: Web-Based Physical-Cognitive Telerehabilitation Exergaming

Control

NO INTERVENTION

Interventions

Web-Based Physical-Cognitive Telerehabilitation Exergaming BEHAVIORAL

Perform a physical-cognitive exergame via ExerbrainCMU web-based platform at home setting for 60 min/session, 3 sessions/week for 12 weeks.

Web-Based Physical-Cognitive Telerehabilitation Exergaming

Eligibility Criteria

• Age: 20 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• diagnosed with ischemic or hemorrhagic stroke at least 6 months before enrollment
• aged between 20 and 80 years
• able to walk at least 10 meters with or without assistive devices
• able to perform sit-to-stand safely with or without assistive devices
• can see the screen of a tablet or notebook computer at a distance of at least 60 cm
• have a stable medical condition and can follow study instructions
• frequent users of a mobile phone, tablet, or notebook computers

You may not qualify if:

• have medical conditions or complications that would be unsafe to exercise
• have neglect, impaired communication, or uncorrected visual problems \[30\], or - have severe spasticity of the upper or lower extremities (Modified Ashworth Scale ≥ 3)

Sponsors & Collaborators

• Chiang Mai University: lead

MeSH Terms

Conditions

Stroke; Motor Activity

Condition Hierarchy (Ancestors)

Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases; Behavior

Study Officials

• Puntarik Keawtep

  Chiang Mai Uiversity

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Puntarik Keawtep, Ph.D., Primary investigator

CONTACT

66 861822590; puntarik.k@cmu.ac.th

Somporn Sungkarat, PhD, Associate Professor

CONTACT

66814458336; somporn.sungkarat@cmu.ac.th

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Model Details: A two-arm, assessor blind, and randomized controlled trial

Study Record Dates

• First Submitted: February 18, 2026
• First Posted: March 3, 2026
• Study Start: February 1, 2026
• Primary Completion (Estimated): November 1, 2026
• Study Completion (Estimated): March 1, 2027
• Last Updated: March 3, 2026

Record last verified: 2026-02

Data Sharing

• IPD Sharing: Will not share