High-Intensity Exercise in Older Adults

NCT06199661 | Completed

• 1 other identifier: 1884
• Study Type: interventional
• Target: 4
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this interventional study was to test the high-intensity interval training called Aphasia Physical Exercise (APEX) in healthy older adults. The main questions it aimed to answer were:

• Baseline testing session (#1) with cognitive measures only (a week before the Pre-exercise session);
• Pre-exercise session (#2) with maximum oxygen consumption and heart rate assessment, functional fitness and cognitive measures (3-7 days before the start of the exercise program);
• APEX program, two APEX classes per week for four weeks (eight classes in total);
• Post-exercise session (#3), functional fitness and cognitive measures, (0-2 days after the end of the exercise program).

Conditions

Functional Fitness; Cognitive Abilities

Outcome Measures

Primary Outcomes (18)

• Attendance Rate

  The number of classes attended out of eight total classes.

  4 weeks during intervention

• Heart Rate

  Heart rate measured in beats per minute.

  4 weeks during intervention

• Functional Reach Test Distance

  The distance in inches of an individual's forward reach with one arm while maintaining a standing position with feet flat on the floor at hip width.

  Once 3-7 days before start of intervention and once 0-2 days after end of intervention

• Timed Up-And-Go Time

  The number of seconds for an individual to rise from a seated position, walk eight feet, turn around, and return to a seated position.

  Once 3-7 days before start of intervention and once 0-2 days after end of intervention

• Number of Steps in 2-minute Step Test

  The number of right knee raises completed in two minutes while marching in place and raising each knee to a point midway between the patella (kneecap) and iliac crest (top hip bone).

  Once 3-7 days before start of intervention and once 0-2 days after end of intervention

• Number of Repetitions in 30-Second Chair Stand Test

  The number of sit-to-stands completed in 30 seconds on a standard 17" seat-height chair with arms folded across the chest.

  Once 3-7 days before start of intervention and once 0-2 days after end of intervention

• Visual Search Task Accuracy

  Number of correct trials

  Once 10-14 days before start of intervention, once 3-7 days before start of intervention, and once 0-2 days after end of intervention

• Visual Search Task Reaction Time

  Reaction time on correct trials in seconds

  Once 10-14 days before start of intervention, once 3-7 days before start of intervention, and once 0-2 days after end of intervention

• Forward Digit Span

  The length of the longest sequence of random digits that a participant can correctly recall twice.

  Once 10-14 days before start of intervention, once 3-7 days before start of intervention, and once 0-2 days after end of intervention

• Backward Digit Span

  The length of the longest sequence of random digits that a participant can correctly report backward twice.

  Once 10-14 days before start of intervention, once 3-7 days before start of intervention, and once 0-2 days after end of intervention

• Forward Spatial Span

  The length of the longest sequence of random positions that a participant can correctly recall.

  Once 10-14 days before start of intervention, once 3-7 days before start of intervention, and once 0-2 days after end of intervention

• Backward Spatial Span

  The length of the longest sequence of random positions that a participant can correctly report backward.

  Once 10-14 days before start of intervention, once 3-7 days before start of intervention, and once 0-2 days after end of intervention

• Go/No-Go Task Hits

  Hits are the proportion of correct responses on trials when "go" is presented.

  Once 10-14 days before start of intervention, once 3-7 days before start of intervention, and once 0-2 days after end of intervention

• Go/No-Go Task Reaction Times

  Reaction times are for hit trials only (correct responses when "go" is presented) in seconds.

  Once 10-14 days before start of intervention, once 3-7 days before start of intervention, and once 0-2 days after end of intervention

• Flanker Task Accuracy

  Number of correct trials.

  Once 10-14 days before start of intervention, once 3-7 days before start of intervention, and once 0-2 days after end of intervention

• Flanker Task Reaction Times

  Reaction time on correct trials in seconds.

  Once 10-14 days before start of intervention, once 3-7 days before start of intervention, and once 0-2 days after end of intervention

• Stroop Task Accuracy

  Number of correct trials.

  Once 10-14 days before start of intervention, once 3-7 days before start of intervention, and once 0-2 days after end of intervention

• Stroop Task Reaction Times

  Reaction time on correct trials in seconds.

  Once 10-14 days before start of intervention, once 3-7 days before start of intervention, and once 0-2 days after end of intervention

Study Arms (1)

APEX

EXPERIMENTAL

Physical exercise intervention based on high-intensity interval training

Behavioral: APEX

Interventions

APEX BEHAVIORAL

Three phases: warm-up, high-intensity interval training (HIIT) phase, cool-down. A 10-minute warm-up included deep breathing meditation and dynamic joint mobility exercises. Then, a 40-minute strength and balance workout in HIIT format with five different high-intensity (HI) exercises interspersed with five different postural stability recovery exercises. The HI intervals focused on enhancing cardiovascular fitness, muscle strength, and motor performance. The recovery intervals incorporated balance and mobility exercises. The HI exercises lasted 30 seconds for the first three weeks and then increased to 45 seconds in the fourth week while the recovery exercises lasted 60 seconds throughout the entire intervention. The HIIT phase was repeated three times in the 40 minute block. Lastly, a 10-minute cooldown consisting of standing and seated exercises similar to the warm-up.

Also known as: Physical exercise intervention incorporating high-intensity interval training

APEX

Eligibility Criteria

• Age: 50 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Between the ages of 50 and 80
• Ambulatory and community-dwelling
• Able to travel to University of San Francisco for weekly exercise classes
• No serious underlying health or neurological conditions

You may not qualify if:

• Inability to complete physical function assessment or inability to do a chair stand without using hands
• Use of antidiabetic medications
• Use of testosterone supplement or replacement
• Clinical disorder precluding/interfering with participation or assessments (identified by Physical Activity Readiness Questionnaire (PAR-Q+)), including: unstable angina, arrhythmia, uncontrolled hypertension, end stage renal disease on hemodialysis, lower extremity amputation or paralysis, neurological conditions causing functional or pronounced cognitive impairments, active malignancy except for non-melanomatous skin cancers
• Previous neurological history such as stroke, traumatic brain injury, multiple sclerosis, long-term pre-stroke seizures, Parkinson's, Alzheimer's, etc.
• Unable to provide consent

Sponsors & Collaborators

• University of California, Berkeley: lead
• University of San Francisco: collaborator

Study Sites (1)

University of San Francisco

San Francisco, California, 94118, United States

Location

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Research Scientist

Study Record Dates

• First Submitted: December 13, 2023
• First Posted: January 10, 2024
• Study Start: March 6, 2023
• Primary Completion: June 1, 2023
• Study Completion: June 1, 2023
• Last Updated: January 10, 2024

Record last verified: 2023-12

Locations

US (1)