Primary Stability and Peri-implant Outcomes of Short Implants in Post-extraction Single-tooth Sites

NCT07177521 | Recruiting DMC

• 1 other identifier: Post-extraction-implants
• Study Type: interventional
• Target: 10
• Locations: 1 country
• Sites: 1

Brief Summary

The placement of short implants in post-extraction sockets is a valuable option when residual bone height is limited, minimizing morbidity and treatment time. The management of the peri-implant gap and soft tissues may influence primary stability, hard/soft tissue remodeling, and implant success.

Conditions

Edentulous Jaw; Tooth Loss; Toothless Mouth

Outcome Measures

Primary Outcomes (1)

• Primary stability

  To compare the primary stability (ISQ values at implant insertion) of short implants placed in post-extraction sockets using the two grafting protocols.

  1 month

Secondary Outcomes (2)

• Clinical Indices

  12 months

• Clinical Indices

  12 month

Study Arms (2)

Group 1

EXPERIMENTAL

Socket grafting with a fully resorbable synthetic biomaterial (β-tricalcium phosphate + calcium sulfate).

Procedure: Insertion of implants in post-extraction tooth

Group 2

ACTIVE COMPARATOR

Socket grafting with a xenograft and a custom Sealing Socket Abutment with a concave emergence profile.

Procedure: Insertion of implants in post-extraction tooth

Interventions

Insertion of implants in post-extraction tooth PROCEDURE

Two widely used approaches include: 1. Socket grafting with a fully resorbable synthetic biomaterial (β-tricalcium phosphate + calcium sulfate). 2. Socket grafting with a xenograft and a custom Sealing Socket Abutment (SSA) with a concave emergence profile. No randomized controlled trials have yet compared these protocols with integrated outcomes including resonance frequency analysis, peri-implant health indices, radiographic bone level changes, and digital intraoral scanning (IOS)-based morphometric analysis.

Group 1; Group 2

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age ≥18 years.
• Single-tooth post-extraction sites requiring immediate implant placement in posterior regions (premolars/molars) or selected anterior sites.
• Planned short implant (≤7-8 mm length, 3.5-5.0 mm diameter).
• Adequate oral hygiene, no active periodontal disease.
• Written informed consent.

You may not qualify if:

• Heavy smoking (\>20 cigarettes/day).
• Uncontrolled diabetes or systemic conditions affecting bone healing.
• Current bisphosphonate/antiresorptive therapy.
• Immunosuppression, pregnancy.
• Poor oral hygiene or acute infection at site.
• Severe bone dehiscence preventing primary stability.

Sponsors & Collaborators

• University of Bari Aldo Moro: lead

Study Sites (1)

University of Bari Aldo Moro

Bari, 70021, Italy

RECRUITING

MeSH Terms

Conditions

Jaw, Edentulous; Tooth Loss; Mouth, Edentulous

Condition Hierarchy (Ancestors)

Jaw Diseases; Musculoskeletal Diseases; Stomatognathic Diseases; Mouth Diseases; Tooth Diseases; Periodontal Diseases

Study Officials

• Giuseppe D'Albis, Dr

  University of Bari Aldo Moro

  PRINCIPAL INVESTIGATOR

• Saverio Capodiferro, Prof

  University of Bari Aldo Moro

  STUDY CHAIR

Central Study Contacts

Giuseppe D'Albis, Dr

CONTACT

+393495103642; giuseppe.dalbis@uniba.it

Saverio Capodiferro

CONTACT

saverio.capodiferro@uniba.it

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: September 8, 2025
• First Posted: September 17, 2025
• Study Start: January 10, 2025
• Primary Completion: June 1, 2026
• Study Completion (Estimated): August 10, 2026
• Last Updated: January 27, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will not share

Locations

IT (1)