Research on the Enhancement of Aerobic Metabolic Energy Supply Capacity by Ischemic Preconditioning.

NCT07170774 | Completed

• 1 other identifier: 2023WCXTD011
• Study Type: interventional
• Target: 16
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this clinical trial is to investigate whether IPC can improve aerobic capacity during exercise. The primary question it aims to answer is: Does IPC enhance the aerobic capacity of athletes? The researchers will compare IPC (220 mmHg pressure) with a placebo (20 mmHg pressure) to see if different interventions can enhance aerobic capacity and exercise performance. Participants will:

• Undergo a randomized crossover controlled trial, visiting twice, with a one-week interval between each test.
• Conduct two assessments at the testing site each time, namely a pre-intervention assessment and a post-intervention assessment.
• Record their heart rate, blood pressure, weight, oxygen uptake, Taekwondo-specific performance, and other indicators.

Conditions

Ischemic Preconditioning; Aerobic Capacity

Keywords

Ischemic preconditioning; Energy metabolism; Sports performance; Oxygen uptake

Outcome Measures

Primary Outcomes (3)

• Oxygen uptake

  To record the oxygen uptake of the subjects and compare the changes in oxygen uptake after the intervention.

  Participants had their oxygen uptake measured continuously during both visits, extending until six minutes after the completion of the exercise test.

• Taekwondo-specific sports performance test

  The specialized athletic ability in Taekwondo is measured by the number of kicks performed during the test.

  The subjects rested quietly for five minutes before baseline measurements were taken. After this, the collection of metabolic gases commenced. Throughout the experiment, metabolic gases were continuously collected until six minutes after the tests.

• Blood lactate

  Used to measure the intensity and metabolic adaptations during the testing process of taekwondo athletes

  Blood lactate levels were measured at baseline, immediately after the intervention at 3 minutes, and at 3 and 10 minutes post-testing.

Study Arms (2)

IPC Trial

EXPERIMENTAL

220 mmHg

Device: Ischemic Preconditioning

SHAM Trial

PLACEBO COMPARATOR

20 mmHg

Device: Sham

Interventions

Ischemic Preconditioning DEVICE

Compression cuff width: 10CM; Compression duration: 5min/5min (ischemia/reperfusion) \*4. 220 mmHg

IPC Trial

Sham DEVICE

Compression cuff width: 10CM; Compression duration: 5min/5min (compression/relaxation) \*4. 20 mmHg

SHAM Trial

Eligibility Criteria

• Age: 18 Years - 22 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• adult male athletes aged 18 years or older;
• taekwondo athletes classified as national second-class or above (having placed in the top three provincial professional taekwondo championships or the top eight national professional taekwondo championships);
• consistent and unified training over the past three months;
• no prior ischemic preconditioning;
• competitive taekwondo athletes.

You may not qualify if:

• supplementation with creatine;
• acute or chronic illnesses, including anxiety, depression, cardiovascular diseases, and metabolic disorders;
• engaging in vigorous physical activity within 48 hours prior to the experiment;
• consuming alcohol or caffeine within 24 hours before the experiment.

Sponsors & Collaborators

• Ziyue Ou: lead

Study Sites (1)

Guangzhou Sport University

Guangzhou, 510500, China

Location

Related Publications (4)

• Cheng CF, Kuo YH, Hsu WC, Chen C, Pan CH. Local and Remote Ischemic Preconditioning Improves Sprint Interval Exercise Performance in Team Sport Athletes. Int J Environ Res Public Health. 2021 Oct 12;18(20):10653. doi: 10.3390/ijerph182010653.

  PMID: 34682399 BACKGROUND

• Chen Y, Yang J, Muradov O, Li X, Lee JKW, Qiu J. Effect of ischemic preconditioning on maximum accumulated oxygen deficit in 400-meter runners. Eur J Sport Sci. 2023 May;23(5):789-796. doi: 10.1080/17461391.2022.2064769. Epub 2022 Apr 25.

  PMID: 35400298 BACKGROUND

• Caru M, Levesque A, Lalonde F, Curnier D. An overview of ischemic preconditioning in exercise performance: A systematic review. J Sport Health Sci. 2019 Jul;8(4):355-369. doi: 10.1016/j.jshs.2019.01.008. Epub 2019 Jan 23.

  PMID: 31333890 BACKGROUND

• Albuquerque MR, Flor CAG, Ribeiro AIS, Mesquita PHC, Franchini E, Laurentino GC. Effects of Ischemic Preconditioning on Sport-Specific Performance in Highly Trained Taekwondo Athletes. Sports (Basel). 2024 Jun 26;12(7):179. doi: 10.3390/sports12070179.

  PMID: 39058070 BACKGROUND

MeSH Terms

Interventions

Ischemic Preconditioning

Intervention Hierarchy (Ancestors)

Therapeutics; Investigative Techniques

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: OTHER
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Sponsor-Investigator

Study Record Dates

• First Submitted: September 7, 2025
• First Posted: September 12, 2025
• Study Start: April 1, 2024
• Primary Completion: June 1, 2024
• Study Completion: June 1, 2024
• Last Updated: September 12, 2025

Record last verified: 2025-09

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)