Carcinogen and Toxicant Exposure Among Young Adults Who Co-Use E-cigarettes and Cannabis (Co-Tox Study)

NCT07167225 | Recruiting

• 1 other identifier: I-4235024
• Study Type: observational
• Target: 150
• Locations: 1 country
• Sites: 1

Brief Summary

This study evaluates the amount of nicotine, cannabis, and toxicants linked to the use of nicotine e-cigarette and/or cannabis products in the blood and urine of young adult users as well as the cannabis and nicotine use behaviors of consumers.

Conditions

Cigarette Smoking-Related Carcinoma; E-Cig Use

Outcome Measures

Primary Outcomes (1)

• Differences in biomarker levels across groups

  Will compare the mean biomarker levels between groups using a one-way ANOVA model, with Bonferroni-adjusted pairwise comparisons, as appropriate.

  1 study session lasting 1 hour

Secondary Outcomes (6)

• Differences in self reported nicotine and cannabis use behaviors

  1 study session (1 hour)

• Differences in psychosocial characteristics by group

  1 study session (1 hour)

• Study interest

  Up to 1 year

• Recall of study recruitment advertisement type

  1 study session (1 hour)

• Recall of recruitment channel

  1 study session (1 hour)

Study Arms (3)

E-cigarette consumers

Predominant e-cigarette consumers

Other: Effectiveness of different recruitment approaches; Other: Choice of study completion locations; Other: E-cigarette dependence Scale

Cannabis consumers

Predominant cannabis consumers

Other: Effectiveness of different recruitment approaches; Other: Choice of study completion locations; Other: Cannabis Engagement Assessment

e-cigarette -cannabis coconsumers

Consumers who use both e-cigarettes and cannabis .

Other: Effectiveness of different recruitment approaches; Other: Choice of study completion locations; Other: Cannabis Engagement Assessment; Other: E-cigarette dependence Scale

Interventions

Effectiveness of different recruitment approaches OTHER

Subjects will asked which type of recruitment material they've seen when completing the screening survey

Cannabis consumers; E-cigarette consumers; e-cigarette -cannabis coconsumers

Choice of study completion locations OTHER

subjects will choose location when coordinator calls to schedule appointment

Cannabis consumers; E-cigarette consumers; e-cigarette -cannabis coconsumers

Cannabis Engagement Assessment OTHER

Self reported measure of current cannabis use that contains 30 questions assessing quantity, frequency of use and method of consumption in the past 30 days.

Cannabis consumers; e-cigarette -cannabis coconsumers

E-cigarette dependence Scale OTHER

A 22-item questionnaire measuring e-cigarette dependence. Higher scores indicate greater dependence.

E-cigarette consumers; e-cigarette -cannabis coconsumers

Eligibility Criteria

• Age: 18 Years - 25 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Probability Sample

Study Population

Young adults (18-25 year old) currently using cannabis products and/or electronic cigarettes containing nicotine.

You may qualify if:

• Young adult (18-25 years old).
• Ability to read and write in English.
• Participants must fall into one of the following groups (based on self-report):
• Predominant e-cigarette consumer: defined as using nicotine-containing e-cigarettes daily for the past six months but not having used other nicotine containing products more than weekly or cannabis products for the past month.
• Predominant cannabis consumer: defined as using cannabis at least 3x/week for the past six months in any form, including smoking, vaping, and oral use, with no more than weekly use of any nicotine or tobacco products.
• E-cigarette-cannabis co-consumers: defined as daily use of nicotine e-cigarettes and use of cannabis at least 3x/week, including smoking, vaping, and oral use, for at least the past six months, with no use of other nicotine containing products more than weekly.
• No self-reported diagnosis of kidney disease (current, or within the past year prior to the study visit).
• Participants must understand the voluntary nature of this study and sign a written informed consent form before proceeding with study activities.

You may not qualify if:

• Individuals under the age of 18 or over the age of 25.
• Currently pregnant or breastfeeding (female participants).
• Unwilling or unable to follow protocol requirements

Sponsors & Collaborators

• Roswell Park Cancer Institute: lead

Study Sites (1)

Roswell Park Comprehensive Cancer Center

Buffalo, New York, 14263, United States

RECRUITING

MeSH Terms

Conditions

Vaping

Condition Hierarchy (Ancestors)

Smoking; Behavior

Study Officials

• Danielle Smith, PhD

  Roswell Park

  PRINCIPAL INVESTIGATOR

Central Study Contacts

ASK RPCI

CONTACT

1-800-767-9355; askroswell@roswellpark.org

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 27, 2025
• First Posted: September 11, 2025
• Study Start: April 3, 2025
• Primary Completion (Estimated): September 1, 2028
• Study Completion (Estimated): September 1, 2028
• Last Updated: October 3, 2025

Record last verified: 2025-09

Locations

US (1)