Periodontal Pathogens and Atherom Plaque The Number of Mitochondrial DNA Copies

NCT07165054 | Completed

• 1 other identifier: 1
• Study Type: observational
• Target: 51
• Locations: 1 country
• Sites: 1

Brief Summary

Periodontitis is a chronic inflammatory disease of the tooth-supporting tissues characterized by the constant interaction of microorganisms in subgingival plaque and host defense mechanisms. Periodontitis is considered a focus of infection caused by oral bacteria, bacterial byproducts, or inflammatory mediators that can interact with other parts of the body via the bloodstream.

Conditions

Periodontal Inflammation; Biofilm; Endothelial Dysfunction; Oral Bacteria

Outcome Measures

Primary Outcomes (1)

• Bacterial frequency (%)

  The percentage of bacteria in the red complex in atheroma plaque and dental plaque is evaluated using polymerase chain reaction methods.

  Months 6-9 of the study

Secondary Outcomes (2)

• Changes in mtDNA copy number (number)

  Months 6-9 of the study

• periodontal healths (mm)

  8 months

Study Arms (1)

Patients diagnosed with endarterectomy

Other: atheroma plaque; Other: Dental plaque

Interventions

atheroma plaque OTHER

Before the endarterectomy procedure, samples will be collected for study from some of the atheroma plaques routinely taken for pathology from patients.

Patients diagnosed with endarterectomy

Dental plaque OTHER

Subgingival plaque samples will be collected from patients before the endarterectomy procedure.

Patients diagnosed with endarterectomy

Eligibility Criteria

• Age: 25 Years - 90 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Endearterectomy diagnosed, dentate and edentulous patients

You may qualify if:

• Diagnosed with endarterectomy
• Not receiving chemotherapy
• Not having received this treatment before

You may not qualify if:

• Having systemic infection
• Patients with severe heart disease

Sponsors & Collaborators

• Istanbul Saglik Bilimleri University: lead

Study Sites (1)

Health Sciences University, Hamidiye Faculty of Dentistry, Department of Periodontology

Istanbul, Turkey (Türkiye)

Location

MeSH Terms

Interventions

Dental Plaque Index

Intervention Hierarchy (Ancestors)

Dental Health Surveys; Health Surveys; Surveys and Questionnaires; Data Collection; Epidemiologic Methods; Investigative Techniques; Dentistry; Health Care Evaluation Mechanisms; Quality of Health Care; Health Care Quality, Access, and Evaluation; Public Health; Environment and Public Health; Public Health Dentistry

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: associate professor

Study Record Dates

• First Submitted: September 3, 2025
• First Posted: September 10, 2025
• Study Start: April 10, 2025
• Primary Completion: November 1, 2025
• Study Completion: December 1, 2025
• Last Updated: January 30, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)