Bacteria in Dental Plaque and Atheroma Plaque

NCT07100574 | Recruiting

• 1 other identifier: 1417
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

Periodontitis is considered a focus of infection where oral bacteria, bacterial by-products or inflammatory mediators can interact with other parts of the organism via the blood. Periodontal pathogen components such as DNA, RNA or specific antigens of P. gingivalis, Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans), Treponema denticola (T. denticola), Fusobacterium nucleatum (F. nucleatum) or Campylobacter rectus have been isolated from different tissues such as atheroma plaques, placenta, amniotic sac and respiratory tract. It has been reported that periodontitis may contribute to endothelial dysfunction leading to the formation of atherosclerosis.

Conditions

Gingival Inflammation; Dental Plaque; Atheroma Plaque; Oral Bacteria

Outcome Measures

Primary Outcomes (2)

• Number of bacteria

  Subgingival plaque

  through study completion, an average of 2 months

• Number of bacteria

  atheroma plaque

  through study completion, an average of 2 months

Study Arms (1)

Patients diagnosed with endarterectomy

Other: atheroma plaque; Other: dental plaque

Interventions

atheroma plaque OTHER

During the endarterectomy procedure, samples will be collected for study from some of the atheroma plaques routinely taken for pathology from patients.

Patients diagnosed with endarterectomy

dental plaque OTHER

Subgingival plaque samples will be collected from patients before the endarterectomy procedure.

Patients diagnosed with endarterectomy

Eligibility Criteria

• Age: 18 Years - 85 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Endearterectomy diagnosed, dentate and edentulous patients

You may qualify if:

• Diagnosed with endarterectomy
• Not receiving chemotherapy
• Not having received this treatment before

You may not qualify if:

• Having systemic infection
• Patients with severe heart disease

Sponsors & Collaborators

• Istanbul Saglik Bilimleri University: lead

Study Sites (1)

Health Sciences University, Hamidiye Faculty of Dentistry, Department of Periodontology

Istanbul, Turkey (Türkiye)

RECRUITING

MeSH Terms

Conditions

Gingivitis; Dental Plaque

Interventions

Dental Plaque Index

Condition Hierarchy (Ancestors)

Infections; Gingival Diseases; Periodontal Diseases; Mouth Diseases; Stomatognathic Diseases; Dental Deposits; Tooth Diseases

Intervention Hierarchy (Ancestors)

Dental Health Surveys; Health Surveys; Surveys and Questionnaires; Data Collection; Epidemiologic Methods; Investigative Techniques; Dentistry; Health Care Evaluation Mechanisms; Quality of Health Care; Health Care Quality, Access, and Evaluation; Public Health; Environment and Public Health; Public Health Dentistry

Central Study Contacts

Ayşe Toraman

CONTACT

05385025422; draysetoraman@gmail.com

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: associate professor

Study Record Dates

• First Submitted: October 10, 2024
• First Posted: August 3, 2025
• Study Start: December 10, 2024
• Primary Completion: December 30, 2025
• Study Completion: March 30, 2026
• Last Updated: August 3, 2025

Record last verified: 2025-08

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)