Evaluation of Bone Mineral Density Indications and Outcomes in Female Adolescents: Implications for Early Detection of Osteopenia/Osteoporosis and Gynecologic Practice

NCT07164248 | Completed

• 1 other identifier: 2025/05/05/048
• Study Type: observational
• Target: 74
• Locations: 1 country
• Sites: 1

Brief Summary

This retrospective study evaluates bone mineral density (BMD) measurements obtained by dual-energy X-ray absorptiometry (DEXA) in adolescent girls aged 12 to 21 years at a tertiary care center. The study focuses on patients referred from the adolescent gynecology clinic as well as from other medical specialties. Key objectives are: Comparing the BMD indications and results requested from the gynecology department with the indications and BMD results requested from other departments. Thus, the BMD scores of patients with hypogonadism can be compared with other groups at risk for bone health. To assess BMD Z-scores across specific gynecologic diagnoses, including premature ovarian insufficiency, functional hypothalamic amenorrhea (FHA), and hypogonadotropic hypogonadism. To analyze the relationship between gynecologic clinical features-such as age at menarche and duration of amenorrhea-and BMD Z-scores. By combining clinical, hormonal, and densitometric data, this study aims to identify risk factors for low bone density in adolescents, support earlier recognition of osteopenia/osteoporosis, and provide guidance for appropriate interventions in adolescent gynecology practice.

Conditions

Bone Density; Osteopenia; Amenorrhea; Primary Amenorrhea

Keywords

Osteoporosis; Amenorrhea; DEXA; Adolescent; Bone Health; Osteopenia

Outcome Measures

Primary Outcomes (1)

• Bone Mineral Density (BMD) Z-scores in Adolescent Girls

  Comparison of BMD Z-scores between adolescents (12-21 years) referred from the adolescent gynecology clinic and those referred from other specialties.

  At the time of DEXA scan (retrospective chart review, 2020-2025

Study Arms (2)

Cohort 1 - Adolescent gynecology referrals

Patients referred for DEXA scans due to gynecologic indications such as hypogonadism, amenorrhea, premature ovarian insufficiency \[POI\], functional hypothalamic amenorrhea \[FHA\], or hypogonadotropic hypogonadism

Cohort 2 - Referrals from other specialties

Patients referred for DEXA scans by other departments, such as pediatrics, endocrinology, or additional medical specialties

Eligibility Criteria

• Age: 12 Years - 21 Years
• Sex: female
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Female adolescents aged 12-21 years who underwent bone mineral density (BMD) measurement by dual-energy X-ray absorptiometry (DEXA) at a tertiary care hospital. The study includes patients referred from the adolescent gynecology clinic as well as those referred from other medical specialties (e.g., pediatrics, endocrinology).

You may qualify if:

• Female adolescents aged 12-21 years
• Underwent bone mineral density (BMD) measurement with DEXA at the study center between 2020 and 2025
• Available clinical and biochemical records, including referral indication

You may not qualify if:

• Incomplete or missing BMD scan data
• Insufficient clinical information in medical records
• Patients with underlying conditions unrelated to bone health that preclude accurate evaluation (e.g., major skeletal deformities interfering with DEXA interpretation)

Sponsors & Collaborators

• Bagcilar Training and Research Hospital: lead

Study Sites (1)

Bagcilar Training and Research Hospital

Istanbul, 34200, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Bone Diseases, Metabolic; Amenorrhea; Osteoporosis

Condition Hierarchy (Ancestors)

Bone Diseases; Musculoskeletal Diseases; Metabolic Diseases; Nutritional and Metabolic Diseases; Menstruation Disturbances; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Nursen Kurtoglu

  Bagcilar Training and Research Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Obstetrics and Gynecology Specialist, Bagcilar Training and Research Hospital

Study Record Dates

• First Submitted: September 2, 2025
• First Posted: September 10, 2025
• Study Start: June 1, 2025
• Primary Completion: June 15, 2025
• Study Completion: August 1, 2025
• Last Updated: September 15, 2025

Record last verified: 2025-09

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)