Nudge and Motivational Interviewing Interventions to Improve Influenza Vaccine Uptake Among Healthcare Workers in China

NCT07157163 | Not Yet Recruiting DMC

• 1 other identifier: 202529
• Study Type: interventional
• Target: 4,050
• Locations: 0 countries
• Sites: N/A

Brief Summary

The goal of this clinical trial is to learn if nudge-based interventions and motivational interviewing work to improve influenza vaccination uptake among healthcare workers in China. A two-phase randomized controlled trial will be conducted in community hospitals across China, targeting healthcare workers as participants. The main questions are: Do nudge-based interventions increase vaccination rates among healthcare workers? Does motivational interviewing increase vaccination compliance among those who remain unvaccinated after the phase 1? In phase 1, community hospitals will be randomized as units into three arms: standard nudge group, personalized nudge group, and a control group. In phase 2, healthcare workers who remain unvaccinated after phase 1 will be individually randomized to either a motivational interviewing group or a control group. Participants will: Be recruited from community hospitals to participate in the study. In phase 1 (at the early stage of the flu season), community hospitals will be randomly assigned to one of three groups: standardized nudge messages, personalized nudge messages with a chatbot, or no reminders. If still unvaccinated in phase 2 (during peak flu season), healthcare workers will be individually assigned to either motivational interviewing group or receive no extra contact. Have their vaccination status checked at the end of each phase.

Conditions

Influenza Vaccine; Healthcare Workers

Outcome Measures

Primary Outcomes (1)

• Influenza vaccination uptake

  whether participants get vaccinated against influenza, measured by official vaccination system

  2 months post-intervention for each study phase.

Secondary Outcomes (6)

• Influenza vaccine literacy

  Baseline (pre-intervention) and 2 weeks after each intervention phase.

• Influenza vaccine confidence

  Baseline (pre-intervention) and 2 weeks after each intervention phase.

• High perception on influenza risk

  Baseline (pre-intervention) and 2 weeks after each intervention phase.

• Influenza vaccination intention

  Baseline (pre-intervention) and 2 weeks after each intervention phase.

• Recommendation of influenza vaccine to the public.

  Baseline (pre-intervention) and 2 weeks after each intervention phase.

Other Outcomes (2)

• Intervention usability assessment

  2 weeks after each intervention phase.

• Cost of interventions

  Immediately after the completion of each intervention phase.

Study Arms (5)

Phase 1: standardized nudge group

EXPERIMENTAL

Participants receive uniform nudge messages.

Behavioral: Phase 1: standardized nudge messages

Phase 1: personalized nudge group

EXPERIMENTAL

Participants receive tailored nudge messages with access to a chatbot.

Behavioral: Phase 1: personalized nudge messages + chatbot

Phase 1: control group

NO INTERVENTION

Participants receive no study-related interventions.

Phase 2: motivational interviewing group

EXPERIMENTAL

Participants receive motivational interviewing.

Behavioral: Phase 2: motivational Interviewing

Phase 2: control group

NO INTERVENTION

Participants receive no study-related interventions.

Interventions

Phase 1: standardized nudge messages BEHAVIORAL

Participants receive uniform messages designed to encourage influenza vaccination. These messages, grounded in nudge theory, are delivered through a Chinese online platform to promote vaccination uptake.

Phase 1: standardized nudge group

Phase 1: personalized nudge messages + chatbot BEHAVIORAL

Participants receive tailored messages designed to encourage influenza vaccination. These messages, grounded in nudge theory, are delivered through a Chinese online platform to promote vaccination uptake. Additionally, they have access to an interactive chatbot to address questions and provide decision-making support for influenza vaccination.

Phase 1: personalized nudge group

Phase 2: motivational Interviewing BEHAVIORAL

Unvaccinated participants engage in one-on-one motivational interviewing sessions with a trained interviewer.

Phase 2: motivational interviewing group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Full-time employees of community hospitals who remain employed throughout the study period.
• Have not scheduled or received an influenza vaccine between August 2024 and the time of formal enrollment.
• Agree to participate and provide informed consent.

You may not qualify if:

• Participants with medical conditions that contraindicate influenza vaccination.
• Participants who refuse to participate or do not provide informed consent .
• Phase 2: Individual Randomized Controlled Trial
• Healthcare workers from community hospitals who remain unvaccinated after Phase 1, as verified by official records, will be screened.
• A selected subset of these individuals will be invited to participate in Phase 2.
• \- Participants who refuse to participate or do not provide informed consent .

Sponsors & Collaborators

• Centers for Disease Control and Prevention, China: lead

MeSH Terms

Conditions

Influenza, Human

Condition Hierarchy (Ancestors)

Respiratory Tract Infections; Infections; Orthomyxoviridae Infections; RNA Virus Infections; Virus Diseases; Respiratory Tract Diseases

Central Study Contacts

Lixin Hao, PhD

CONTACT

+86 15201347661; haolx@chinacdc.cn

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Masking Details: Data analysts
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Chief Physician of National Immunization Program

Study Record Dates

• First Submitted: August 19, 2025
• First Posted: September 5, 2025
• Study Start: September 1, 2025
• Primary Completion: March 1, 2026
• Study Completion: March 1, 2026
• Last Updated: September 11, 2025

Record last verified: 2025-09

Data Sharing

• IPD Sharing: Will not share