Retrospective Analysis of Quality of Life Changes in Patients Undergoing Parathyroidectomy for End-Stage Renal Disease

NCT07151664 | Not Yet Recruiting

• 1 other identifier: 2024804
• Study Type: observational
• Target: 60
• Locations: 0 countries
• Sites: N/A

Brief Summary

The purpose of this study is to characterize changes in quality of life in patients who had undergone parathyroidectomy for secondary hyperparathyroidism due to end-stage renal disease, based on data extracted from an established database

Conditions

Secondary Hyperparathyroidism Due to Renal Causes; End Stage Renal Failure

Outcome Measures

Primary Outcomes (1)

• Quality of life scores change with respect to time

  Quality of life was assessed using the 36-item Short Form Health Survey (SF-36) scale. Completed responses for each of the 36 items were extracted from the database. Item responses were aggregated to calculate scores for each of the eight dimensions. Scores for each dimension range from 0 to 100, with higher scores indicating better health status

  up to 1 year

Secondary Outcomes (3)

• Anxiety and depression score change with respect to time

  up to 1 year

• Bone pain scores change with respect to time

  up to 1 year

• Length of hospital stay

  an average of 1 week

Study Arms (1)

Quality of life change in patients Undergoing Parathyroidectomy with end-stage renal failure

Quality of Life Progression in PatientsUndergoing Parathyroidectomy WithSecondary Hyperparathyroidism Due to End-stage Renal Failure

Other: Quality of life progression after parathyroidectomy

Interventions

Quality of life progression after parathyroidectomy OTHER

Study the progression of quality of life

Quality of life change in patients Undergoing Parathyroidectomy with end-stage renal failure

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients who had undergone parathyroidectomy for secondary hyperparathyroidism due to end-stage renal disease were included in this study

You may qualify if:

• Age ≥18 years； Patients who had undergone parathyroidectomy for secondary hyperparathyroidism due to end-stage renal disease.

You may not qualify if:

• Patients who underwent kidney transplantation during the study period. Patients with postoperative whole blood parathyroid hormone levels \>300 pg/mL within the first week after surgery.
• Patients with missing postoperative quality of life assessment data.

Sponsors & Collaborators

• West China Hospital: lead

MeSH Terms

Conditions

Renal Insufficiency, Chronic

Condition Hierarchy (Ancestors)

Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Central Study Contacts

Chunling Jiang, PhD

CONTACT

+862885423593; jiangchunling@scu.edu.cn

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: August 25, 2025
• First Posted: September 3, 2025
• Study Start: September 5, 2025
• Primary Completion: December 5, 2025
• Study Completion (Estimated): December 20, 2026
• Last Updated: September 3, 2025

Record last verified: 2025-08

Data Sharing

• IPD Sharing: Will not share