Different Doses of Intravenous Administered Dexamethasone Effecting Brachial Plexus Supraclavicular Block

NCT06389617 | Not Yet Recruiting

• 1 other identifier: USM/JEPeM/KK/24010061
• Study Type: interventional
• Target: 50
• Locations: 0 countries
• Sites: N/A

Brief Summary

To compare the analgesic properties of ultrasound guided supraclavicular block using ropivacaine 0.5% in arteriovenous fistula creation when used in combination with intravenous administered dexamethasone at 4mg and 8 mg as an adjuvant

Conditions

End Stage Renal Failure

Outcome Measures

Primary Outcomes (2)

• To compare the difference of onset time between sensory and motor block of supraclavicular block between ropivacaine with IV dexamethasone 4mg and ropivacaine with IV dexamethasone 8mg

  2 days

• To compare the difference in duration of analgesia between supraclavicular block with ropivacaine and IV dexamethasone 4mg with ropivacaine and IV dexamethasone 8mg

  2 days

Secondary Outcomes (1)

• To compare the duration difference of the return of motor block between supraclavicular block using ropivacaine with IV dexamethasone 4mg and ropivacaine with IV dexamethasone 8mg

  2 days

Study Arms (2)

GROUP DF

ACTIVE COMPARATOR

supraclavicular block with 20mls of Ropivacaine 0.5% and Intravenous dexamethasone 4mg

Drug: supraclavicular block with 20mls of Ropivacaine 0.5% and Intravenous administered dexamethasone

GROUP DE

ACTIVE COMPARATOR

supraclavicular block with 20mls of Ropivacaine 0.5% and Intravenous dexamethasone 8mg

Drug: supraclavicular block with 20mls of Ropivacaine 0.5% and Intravenous administered dexamethasone

Interventions

supraclavicular block with 20mls of Ropivacaine 0.5% and Intravenous administered dexamethasone DRUG

Comparing the onset of sensory, motor block, duration of motor block and analgesic duration

GROUP DE; GROUP DF

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Adult, age 18 to 65 years End stage renal disease patients for AV fistula creation

You may not qualify if:

• Not suitable candidate as determined by the primary team Refusal for brachial plexus block History of allergy to dexamethasone or local anesthesia Pregnancy History of previous brachial plexus injury Coagulopathy Local skin site infection Known neuropathy involving the arm undergoing surgery Patients with glucose reading more then 12mmol/

Sponsors & Collaborators

• Hospital Universiti Sains Malaysia: lead

MeSH Terms

Conditions

Renal Insufficiency, Chronic

Condition Hierarchy (Ancestors)

Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, CARE PROVIDER
• Purpose: SUPPORTIVE CARE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dr

Study Record Dates

• First Submitted: April 24, 2024
• First Posted: April 29, 2024
• Study Start: May 1, 2024
• Primary Completion: November 30, 2024
• Study Completion: December 30, 2024
• Last Updated: April 29, 2024

Record last verified: 2024-04