Bovine Bone With or Without Concentrated Growth Factor in the Treatment of Chronic Periodontitis

NCT07108790 | Completed

• 1 other identifier: R-OMPDR-3-22-11
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study is to compare bovine bone with or without concentrated growth factor in the treatment of chronic periodontitis.

Conditions

Bovine Bone; Concentrated Growth Factor; Chronic Periodontitis

Outcome Measures

Primary Outcomes (1)

• Probing Pocket depth

  Probing Pocket depth (PPD) was measured.

  6 months post-procedure

Secondary Outcomes (3)

• Clinical attachment level

  6 months post-procedure

• Bleeding on probing

  6 months post-procedure

• Plaque index

  6 months post-procedure

Study Arms (2)

Group Ι

EXPERIMENTAL

Ten sites were treated by concentrated growth factors (CGF), collagen membrane, and xenograft bone graft.

Other: Concentrated growth factors, collagen membrane and xenograft bone graft

Group ΙΙ

ACTIVE COMPARATOR

Ten sites were treated with a collagen membrane and a xenograft bone graft.

Other: Collagen membrane and xenograft bone graft

Interventions

Concentrated growth factors, collagen membrane and xenograft bone graft OTHER

Ten sites were treated by concentrated growth factors (CGF), collagen membrane, and xenograft bone graft.

Group Ι

Collagen membrane and xenograft bone graft OTHER

Ten sites were treated with a collagen membrane and a xenograft bone graft.

Group ΙΙ

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Presence of angular periodontal intra-bony defects with a pocket depth (PD) ≥ 5mm.
• Optimal compliance as evidenced by no missed treatment appointments and a positive attitude towards oral hygiene.
• Full-mouth bleeding score ≤ 25%.

You may not qualify if:

• Patients with relevant medical conditions that may affect periodontal regeneration and periodontal surgery.
• Patients who have any disease or take any medication that affects the normal number or function of platelets.
• Smokers.
• Pregnant or lactating women.
• Patients in whom periodontal surgery had previously been carried out on the selected site.
• Patients with aggressive periodontitis.

Sponsors & Collaborators

• Tanta University: lead

Study Sites (1)

Tanta University

Tanta, El-Gharbia, 31527, Egypt

Location

MeSH Terms

Conditions

Chronic Periodontitis

Condition Hierarchy (Ancestors)

Periodontitis; Periodontal Diseases; Mouth Diseases; Stomatognathic Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: B.D.S of Oral Medicine, Periodontology, Oral Diagnosis & Oral Radiology, Faculty of Dentistry, Tanta University, Tanta, Egypt.

Study Record Dates

• First Submitted: July 31, 2025
• First Posted: August 7, 2025
• Study Start: March 1, 2022
• Primary Completion: January 1, 2025
• Study Completion: January 1, 2025
• Last Updated: August 7, 2025

Record last verified: 2025-07

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL
• Time Frame: After the end of study for one year.
• Access Criteria: The data will be available upon a reasonable request from the corresponding author.

Locations

EG (1)