Clinical & Radiographic Evaluation of Concentrated Growth Factors (CGF) With Auto Transplanted Closed Apex Teeth

NCT07538921 | Not Yet Recruiting DMC

• 1 other identifier: CU-OMFS-CGF-AT-01-2026
• Study Type: interventional
• Target: 7
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to clinically and radiographically evaluate the effect of Concentrated Growth Factors (CGF) on the outcomes of autotransplantation of closed apex teeth. Tooth autotransplantation is considered a viable treatment option for replacing missing teeth; however, its success may be influenced by factors such as periodontal healing and pulpal revascularization, especially in teeth with closed apices. Concentrated Growth Factors (CGF), as an advanced generation of platelet concentrates, are rich in growth factors that may enhance tissue regeneration, promote healing, and improve the success rate of transplanted teeth. In this study, patients requiring tooth autotransplantation will be treated using CGF at the recipient site. Clinical outcomes, including tooth stability, periodontal health, and presence of complications, will be assessed. Radiographic evaluation will be performed to monitor bone healing, root resorption, and periodontal ligament integrity over a defined follow-up period. The findings of this study are expected to provide evidence regarding the potential benefits of CGF in improving the success and prognosis of autotransplanted closed apex teeth.

Conditions

Concentrated Growth Factor

Keywords

closed apex teeth AT

Outcome Measures

Primary Outcomes (1)

• Changes in Radiographic Bone Density at the Recipient Site

  Radiographic assessment of bone density at the recipient site will be performed using CBCT imaging to evaluate bone healing over time.

  6 months

Study Arms (1)

CGF assisted auto transplantation

EXPERIMENTAL

Participants in this arm will undergo autotransplantation of teeth with closed apices using a standardized surgical protocol. Concentrated Growth Factors (CGF) will be prepared from the patient's own blood and applied to the recipient site prior to placement of the donor tooth. The transplanted tooth will then be stabilized using an appropriate splinting technique. Patients will be followed up clinically and radiographically to assess healing outcomes and treatment success.

Procedure: closed apex teeth auto transplantation

Interventions

closed apex teeth auto transplantation PROCEDURE

In this study, autotransplantation of teeth with closed apices will be performed following standard surgical protocols. The donor tooth will be atraumatically extracted with maximum preservation of the periodontal ligament, and the recipient socket will be carefully prepared to receive the transplanted tooth. In the intervention group, Concentrated Growth Factors (CGF) will be prepared from the patient's venous blood using a standardized centrifugation protocol. The obtained CGF will be applied to the recipient socket prior to placement of the donor tooth to enhance healing and promote tissue regeneration.

CGF assisted auto transplantation

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Donor Tooth : any 3rd molar tooth with fully developed roots (confirmed radiographically) and not functionally used (semi impacted, impacted but easily to be extracted, absence of the opposing etc…) .
• Recipient Site : Recipient 1st or 2nd molar region (either upper or lower) with adequate bone volume to receive the auto transplanted tooth.
• Oral Health: Good general oral hygiene and absence of active periodontal disease.
• Systemic Health: patients with no contraindications for minor oral surgery.

You may not qualify if:

• Poor Oral Hygiene: Presence of uncontrolled gingivitis or periodontitis.
• Systemic Conditions: Patients with systemic diseases that may impair healing (e.g., uncontrolled diabetes, immunosuppression, bleeding disorders or bone metabolic diseases ).
• Smoking: Active smokers or tobacco users.
• Pregnancy or Lactation: Female patients who are pregnant or breastfeeding

Sponsors & Collaborators

• Cairo University: lead

Study Sites (1)

Faculty of oral and dental surgery cairo university

Cairo, Elmanial, Egypt

Location

Related Publications (3)

• Keranmu D, Ainiwaer A, Nuermuhanmode N, Ling W. Application of concentrated growth factor to autotransplantation with inflammation in recipient area. BMC Oral Health. 2021 Oct 30;21(1):556. doi: 10.1186/s12903-021-01915-3.

  PMID: 34717618 RESULT

• Czochrowska EM, Stenvik A, Bjercke B, Zachrisson BU. Outcome of tooth transplantation: survival and success rates 17-41 years posttreatment. Am J Orthod Dentofacial Orthop. 2002 Feb;121(2):110-9; quiz 193. doi: 10.1067/mod.2002.119979.

  PMID: 11840123 RESULT

• Chen J, Wan Y, Lin Y, Jiang H. Considerations for Clinical Use of Concentrated Growth Factor in Maxillofacial Regenerative Medicine. J Craniofac Surg. 2021 Jun 1;32(4):1316-1321. doi: 10.1097/SCS.0000000000007182.

  PMID: 33055562 RESULT

Study Officials

• Nesrine Mohammed Khairy, Professor of OMFS

  Cairo University

  STUDY CHAIR

• Abdelmoez Mohamed El-Sharkawy, Associate Professor

  Cairo University

  STUDY DIRECTOR

• Ahmed Mohamed Sayed, master degree

  Cairo University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Ahmed Mohamed Sayed, Master Degree

CONTACT

01125547882; ahmed_sayed@dentistry.cu.edu.eg

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: OTHER
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Doctor

Model Details: A Case series Study

Study Record Dates

• First Submitted: April 13, 2026
• First Posted: April 20, 2026
• Study Start (Estimated): June 1, 2026
• Primary Completion (Estimated): June 1, 2027
• Study Completion (Estimated): July 1, 2027
• Last Updated: May 7, 2026

Record last verified: 2026-04

Locations

EG (1)