Exploring Perceptual Learning in Blurred Gabor Discrimination for Low-Myopic Children

NCT07107646 | Enrolling By Invitation

• 1 other identifier: 202504046RIND
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

This exploratory study investigates whether perceptual learning using blurred Gabor stimuli can improve uncorrected distance visual acuity in children aged 6-10 years with low myopia. Participants will be randomly assigned to a training group or control group. The training group will undergo individualized visual perceptual learning through a digital Vision Training System (VTS) for approximately 3 months. The study will also evaluate changes in refraction, contrast sensitivity, visual crowding, Chinese reading acuity with eye movements, and sweep visual evoked potentials (sVEPs).

Conditions

Myopia; Visual Rehabilitation; Perceptual Learning

Keywords

Low Myopia; Perceptual Learning; Visual Acuity; Visual Evoked Potentials

Outcome Measures

Primary Outcomes (1)

• Change in Best Corrected Visual Acuity (BCVA) From Baseline

  Best Corrected Visual Acuity (BCVA) will be measured using the ETDRS or Snellen chart at a distance of 3 meters under standardized lighting conditions. The change in BCVA from baseline to post-training will be assessed.

  From enrollment to 12 months after completion of the 3-month training program

Secondary Outcomes (5)

• Change in Spherical Equivalent Refraction (Diopters) From Baseline

  From enrollment to 12 months after completion of the 3-month training program

• Change in Contrast Sensitivity Across Spatial Frequencies From Baseline

  From enrollment to 12 months after completion of the 3-month training program

• Change in Visual Crowding Acuity From Baseline

  From enrollment to 12 months after completion of the 3-month training program

• Change in Reading Visual Acuity and Eye Movement Parameters From Baseline

  From enrollment to 12 months after completion of the 3-month training program

• Change in Visual Acuity Measured by Sweep Visual Evoked Potentials (sVEP) From Baseline

  From enrollment to 12 months after completion of the 3-month training program

Study Arms (2)

Visual Perceptual Learning Group

EXPERIMENTAL

Children aged 6-10 years with low myopia will receive a structured visual perceptual learning (VPL) intervention using computerized blurred Gabor discrimination tasks. Training will be conducted at least twice per week, with each session lasting approximately 15-30 minutes, for up to 3 months. Training parameters will be remotely monitored and adjusted based on individual progress. Participants will undergo baseline, post-training, and follow-up assessments of uncorrected visual acuity, refractive error, contrast sensitivity, visual crowding, Chinese reading visual acuity, eye movement performance, and sweep visual evoked potentials (sVEP).

Behavioral: vision training system, VTS

Control Group

NO INTERVENTION

Children aged 6-10 years with low myopia who meet the same inclusion and exclusion criteria will not receive the VPL training during the study period. They will undergo the same schedule of baseline, post-study, and follow-up assessments as the experimental group, including evaluations of uncorrected visual acuity, refractive error, contrast sensitivity, visual crowding, Chinese reading visual acuity, eye movement performance, and sweep visual evoked potentials (sVEP).

Interventions

vision training system, VTS BEHAVIORAL

Participants in this group will receive individualized visual perceptual learning using the Vision Training System (VTS). The training involves blurred Gabor stimuli presented via a computer-based application. Each participant will complete approximately 20 training sessions over 3 months, with each session lasting 15 to 30 minutes, conducted twice per week. The program is designed to enhance uncorrected visual acuity, contrast sensitivity, and other visual functions by engaging neural mechanisms related to perceptual learning. Training progression is adaptive based on individual performance. The VTS software was developed in collaboration with Bar Ilan University.

Visual Perceptual Learning Group

Eligibility Criteria

• Age: 6 Years - 10 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17)

You may qualify if:

• Children aged between 6 to 10 years.
• Best corrected distance visual acuity of 6/6 or 0.00 logMAR.
• Diagnosed with low myopia after a comprehensive ophthalmologic examination, with a spherical equivalent refractive error ranging from -0.50 to -1.25 diopters, including up to -0.75 diopters of astigmatism.
• Not currently undergoing any of the four standard myopia control treatments for children:
• Atropine (mydriatic agent)
• Orthokeratology
• Peripheral defocus soft contact lenses
• Peripheral defocus spectacle lenses (frame glasses)
• Willing and able to provide informed consent, and able to comply with study procedures and assessments.

You may not qualify if:

• Participants will be excluded if they have any of the following ophthalmologic conditions:
• Strabismus
• Binocular vision problems
• Ocular diseases
• History of ocular surgery (excluding refractive surgery)

Sponsors & Collaborators

• National Taiwan University Hospital: lead

Study Sites (1)

Department of Occupational Therapy, College of Medicine, National Taiwan University

Taipei, Taiwan

Location

MeSH Terms

Conditions

Myopia

Interventions

Tidal Volume

Condition Hierarchy (Ancestors)

Refractive Errors; Eye Diseases

Intervention Hierarchy (Ancestors)

Inspiratory Capacity; Vital Capacity; Total Lung Capacity; Lung Volume Measurements; Respiratory Function Tests; Diagnostic Techniques, Respiratory System; Diagnostic Techniques and Procedures; Diagnosis; Respiratory Physiological Phenomena; Circulatory and Respiratory Physiological Phenomena

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 30, 2025
• First Posted: August 6, 2025
• Study Start: August 1, 2025
• Primary Completion (Estimated): June 30, 2027
• Study Completion (Estimated): July 31, 2027
• Last Updated: November 18, 2025

Record last verified: 2025-09

Data Sharing

• IPD Sharing: Will not share

Locations

TW (1)