NCT07101341

Brief Summary

This study aims to compare the acute effects at the cardiovascular (heart rate, blood pressure) and physiological (lactate) levels, as well as the perception of effort and fatigue, of four exercise modalities, one based on the traditional aerobic training methodology, another based on high-intensity interval training (HIIT), another consisting of aerobic exercise performed in conjunction with an immersive virtual reality (VR) application, and a last one consisting of exercise with HIIT-type parameters but also performed in conjunction with an immersive VR application. All participants will complete one session of each of the four exercise modalities, analyzing the variables studied in each for subsequent analysis and comparison.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
45

participants targeted

Target at P25-P50 for not_applicable

Timeline
10mo left

Started Feb 2026

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Progress34%
Feb 2026Jun 2027

First Submitted

Initial submission to the registry

July 22, 2025

Completed
12 days until next milestone

First Posted

Study publicly available on registry

August 3, 2025

Completed
7 months until next milestone

Study Start

First participant enrolled

February 25, 2026

Completed
1.3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 1, 2027

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

June 1, 2027

Last Updated

June 10, 2026

Status Verified

June 1, 2026

Enrollment Period

1.3 years

First QC Date

July 22, 2025

Last Update Submit

June 8, 2026

Conditions

Keywords

virtual realityimmersive virtual realityexergame

Outcome Measures

Primary Outcomes (1)

  • Blood lactate

    Analysis of blood lactate concentration

    During the 5 minutes after finishing the exercise session of each intervention modality (Days 1, 8, 15 and 22 from the start of the study)

Secondary Outcomes (5)

  • Heart rate pattern

    During each exercise session (Days 1, 8, 15 and 22 from the start of the study)

  • Systolic and diastolic blood pressure

    During the 5 minutes after finishing the exercise session of each intervention modality (Days 1, 8, 15 and 22 from the start of the study)

  • Perception of effort

    During the first minute after finishing the exercise session of each intervention modality (Days 1, 8, 15 and 22 from the start of the study)

  • Perception of fatigue

    During the first minute after finishing the exercise session of each intervention modality (Days 1, 8, 15 and 22 from the start of the study)

  • Physical performance

    During the 5 minutes after finishing the exercise session of each intervention modality (Days 1, 8, 15 and 22 from the start of the study)

Study Arms (4)

Traditional aerobic exercise

EXPERIMENTAL
Procedure: Traditional aerobic training

High-intensity interval training

EXPERIMENTAL

A single session of exercise

Procedure: High Intensity Interval Training (HIIT)

Aerobic exercise applied with reality virtual

EXPERIMENTAL

A single session of exercise

Procedure: Aerobic training performed with a immersive virtual reality application

High-intensity interval training applied with virtual reality

EXPERIMENTAL

A single session of exercise

Procedure: High Intensity Interval Training (HIIT) performed with a immersive virtual reality application

Interventions

5 minutes of warm-up at increasing intensity up to 60% of maximum heart rate (HRmax) + 20 minutes between 60-80% of HRmax + 5 minutes of cool-down at decreasing intensity (30-60% HRmax)

Traditional aerobic exercise

5 minutes warm-up at increasing intensity up to 60% maximum heart rate (HRmax) + 20 minutes main part consisting of 10 repetitions of the combination of 1 minute at 75-90% HRmax and 2 minutes of active rest with light pedaling (50% HRmax) + 5 minutes cool-down at decreasing intensity (30-60% HRmax)

High-intensity interval training

5 minutes of warm-up at increasing intensity up to 60% Maximum heart rate (HRmax) + 20 minutes between 60-80% of HRmax + 5 minutes of cooling at decreasing intensity (30-60% HRmax), with the use of virtual reality glasses and an immersive virtual reality application

Aerobic exercise applied with reality virtual

5 minutes warm-up at increasing intensity up to 60% Maximum heart rate (HRmax) + 20 minutes main part consisting of 10 repetitions of the combination of 1 minute at 75-90% HRmax and 2 minutes of active rest with light pedaling (50% HRmax) + 5 minutes cool-down at decreasing intensity (30-60% HRmax), with the use of virtual reality glasses for an immersive virtual reality application

High-intensity interval training applied with virtual reality

Eligibility Criteria

Age18 Years - 35 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Healthy people between 18 and 35 years old

You may not qualify if:

  • Current or recent injury that affects training
  • Condition that prevents exercise (decompensated heart disease, decompensated respiratory disease, significant mobility difficulties, etc.)
  • Visual problems that prevent exercise with virtual reality headsets

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Faculty of Physiotherapy, University of Valencia

Valencia, Valencia, 46010, Spain

RECRUITING

MeSH Terms

Interventions

High-Intensity Interval Training

Intervention Hierarchy (Ancestors)

Physical Conditioning, HumanExerciseMotor ActivityMovementMusculoskeletal Physiological PhenomenaMusculoskeletal and Neural Physiological Phenomena

Study Officials

  • Adrian Escriche-Escuder, PhD

    University of Valencia

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Adrian Escriche-Escuder, PhD

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
INVESTIGATOR, OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
CROSSOVER
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Assistant professor

Study Record Dates

First Submitted

July 22, 2025

First Posted

August 3, 2025

Study Start

February 25, 2026

Primary Completion (Estimated)

June 1, 2027

Study Completion (Estimated)

June 1, 2027

Last Updated

June 10, 2026

Record last verified: 2026-06

Locations