Amyloid PET Imaging in the Baltimore Longitudinal Study of Aging
2 other identifiers
observational
400
1 country
1
Brief Summary
Background: Some people experience cognitive decline as they age. That is, they lose memory, problem-solving, and other mental abilities. Amyloids are groups of proteins that develop in the brain and increase in number as people age. Researchers want to use imaging scans to track amyloids in people s brains over time. Their goal is to find out if any changes are related to cognitive decline or other medical issues. Objective: To learn how amyloids may affect brain structure and function as people age. Eligibility: People aged 55 years and older who are enrolled in the Baltimore Longitudinal Study of Aging. Design: Participants will have imaging scans and other tests every 1 to 4 years, depending on their age. Those 80 and older will be scanned yearly. These scans will be done during regular BLSA visits. The scans will be positron emission tomography and computed tomography (PET CT). Participants will be given fluid through a tube inserted into a vein in their arm. The fluid is a tracer that will cause the amyloids to light up in the images. Then they will lie on a bed with their head inside a PET CT scanner. They will lie still for about 30 minutes. Participants will have tests to assess their memory and other mental skills. They will answer questions about their mood and daily life. These tests will take about 40 minutes to complete; they may be done in person or by phone. Participants will give a contact number for someone who can answer questions about the participant s daily routine. These questions may be answered in person or by phone. Participants will be in this study for 5 years.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Apr 2026
Typical duration for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
July 31, 2025
CompletedFirst Posted
Study publicly available on registry
August 1, 2025
CompletedStudy Start
First participant enrolled
April 21, 2026
ExpectedPrimary Completion
Last participant's last visit for primary outcome
December 12, 2029
Study Completion
Last participant's last visit for all outcomes
December 12, 2029
April 16, 2026
March 30, 2026
3.6 years
July 31, 2025
April 15, 2026
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Amyloid accumulation
yearly PET scans
longitudinal
Study Arms (1)
Adults aged 55 and older.
Adults aged 55 and older.
Eligibility Criteria
Men and women over age 55.
You may not qualify if:
- Participants are men and women 55 years and older drawn from the BLSA sample and thus, represent the gender/ethnic characteristics of this study group. Enrollment is defined as the initial imaging session of the planned longitudinal study.
- Participants who lack capacity to consent will not be enrolled in the study. If the participant loses capacity to consent over the course of follow-up they will be removed them from the study. Competency to consent is assessed as part of the BLSA visit and we will not include people who are not competent to provide consent.
- Preexisting central nervous system diseases
- Weight over 300 lbs.
- Active metastatic cancer (except basal cell cancer)
- Implanted electronic hearing devices
- Breast Cancer with radiation treatment
- Lymphoma
- Pacemaker
- Brain tumor
- Shrapnel
- Schizophrenia
- Bipolar disorder
- Epilepsy
- Language barrier that makes it difficult to understand participant.
- +13 more criteria
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
National Institute of Aging, Clinical Research Unit
Baltimore, Maryland, 21224, United States
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Luigi Ferrucci, M.D.
National Institute on Aging (NIA)
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- OTHER
- Sponsor Type
- NIH
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
July 31, 2025
First Posted
August 1, 2025
Study Start (Estimated)
April 21, 2026
Primary Completion (Estimated)
December 12, 2029
Study Completion (Estimated)
December 12, 2029
Last Updated
April 16, 2026
Record last verified: 2026-03-30