Technical Development of Multi-Parametric Renocerebral MRI
1 other identifier
observational
120
1 country
1
Brief Summary
The purpose of the study is to investigate the associations of the age-related changes in the brain, kidneys and cognitive performance in healthy adults by utilizing multiple anatomic and functional MRI methods along with a battery of cognitive tests.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Dec 2026
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
June 15, 2016
CompletedFirst Posted
Study publicly available on registry
July 13, 2016
CompletedStudy Start
First participant enrolled
December 1, 2026
ExpectedPrimary Completion
Last participant's last visit for primary outcome
December 31, 2030
Study Completion
Last participant's last visit for all outcomes
December 31, 2032
October 15, 2025
October 1, 2025
4.1 years
June 15, 2016
October 13, 2025
Conditions
Outcome Measures
Primary Outcomes (3)
MRI measured perfusion for each group
MRI measurements will be summarized for each group by using mean and standard deviation or standard error.
Baseline
MRI measured vascular reactivity for each group
MRI measurements will be summarized for each group by using mean and standard deviation or standard error.
Baseline
Cognitive performance for each group
The total cognitive performance scores will be summarized for each group by using mean and standard deviation or standard error.
Baseline
Study Arms (4)
Group 1
normal 21-35 years old participants
Group 2
normal 36-50 years old participants
Group 3
normal 51-65 years old participants
Group 4
normal 66- 80 years old participants
Interventions
Eligibility Criteria
Normal participants will be recruited for four age groups with the following age ranges: 21 - 35, 36 -50, 51 - 65 and 66 - 80 years. For each subject group, equal number of male and female subjects will be recruited.
You may qualify if:
- English-speaking as primary language
- No hearing loss or uncorrected vision
You may not qualify if:
- Lacking capacity to consent
- Having known history of cardiovascular diseases (e.g., clinical stroke)
- Having acute and chronic obstructive pulmonary disease
- Having known history of renal diseases (e.g., acute kidney injury)
- Having known history of cognitive disorder or psychiatric illness
- Having known history of chemical dependence (e.g., alcohol and narcotics)
- Being treated with stimulant medications, anticonvulsants, antihypertensives or ß-adrenergic blockers
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Center for Magnetic Resonance Research
Minneapolis, Minnesota, 55455, United States
Study Officials
- PRINCIPAL INVESTIGATOR
Xiufeng Li, Ph.D.
University of Minnesota
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- CROSS SECTIONAL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
June 15, 2016
First Posted
July 13, 2016
Study Start (Estimated)
December 1, 2026
Primary Completion (Estimated)
December 31, 2030
Study Completion (Estimated)
December 31, 2032
Last Updated
October 15, 2025
Record last verified: 2025-10
Data Sharing
- IPD Sharing
- Will not share