The PvCO2-PaCO2/CaO2-CvO2 Ratio in Septic Shock

NCT07096284 | Recruiting

• 1 other identifier: SEPSIS_CO2/O2_vs_lactate
• Study Type: observational
• Target: 30
• Locations: 1 country
• Sites: 3

Brief Summary

The ratio of the venous-arterial carbon dioxide partial pressure difference to the arteriovenous oxygen content difference (Pv-aCO₂/Ca-vO₂) may be a marker of anaerobic metabolism in patients with acute circulatory failure. This study aims to assess the prognostic value of the PvCO2-PaCO2/CaO2-CvO2 in the early phase of septic shock.

Conditions

Septic Shock

Keywords

sepsis; anaerobic metabolism

Outcome Measures

Primary Outcomes (1)

• Prognostic value of PvCO2-PaCO2/Ca O2-CvO2 in patients with septic shock

  The ability of PvCO2-PaCO2/Ca O2-CvO2 to predict mortality in patients with septic shock. These biological values will be measure using arterial and central venous blood gaz.

  From patient inclusion (baseilie = H0) then at H2, H6, H 12 and H24 (H = hours)

Study Arms (1)

Adult patients with septic shock.

Patients aged over 18 years presenting with septic shock. defined as sepsis with persistent hypotension requiring vasopressors to maintain a mean arterial pressure (MAP) ≥ 65 mmHg and lactatemia \> 2 mmol/L despite adequate fluid resuscitation.

Diagnostic Test: PvCO2-PaCO2/CaO2-CvO2 ratio

Interventions

PvCO2-PaCO2/CaO2-CvO2 ratio DIAGNOSTIC_TEST

Patients diagnosed with septic shock will undergo serial measurements of arterial and venous blood gas analyses, arterial lactate levels, and calculation of the Pv-aCO₂/Ca-vO₂ ratio at predefined time points: H0 (baseline), H2, H6, H12, and H24. Calculation Formulas: 1. Arterial Oxygen Content (CaO₂):CaO2 = SaO2 × Hb × 1,34 + PaO2 × 0,0031 2. Venous Oxygen Content (CvO₂):CvO2 = SvO2 × Hb × 1,34 + PvO2 × 0,0031 3. Pv-aCO₂/Ca-vO₂ Ratio: P(v-a) CO2/C(a-v)O2=(PcvCO2-PaCO2)/(CaO2 -CcvO2).

Adult patients with septic shock.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients aged over 18 years presenting with septic shock, defined as sepsis with persistent hypotension requiring vasopressors to maintain a mean arterial pressure (MAP) ≥ 65 mmHg and lactatemia \> 2 mmol/L despite adequate fluid resuscitation. Sepsis is defined by the presence of a suspected or confirmed infectious source associated with organ dysfunction (neurological, respiratory, renal, hepatic, or hematological). \[Sepsis 3 criteria\]

You may qualify if:

• Patients aged over 18 years presenting with septic shock, defined as sepsis with persistent hypotension requiring vasopressors to maintain a mean arterial pressure (MAP) ≥ 65 mmHg and lactatemia \> 2 mmol/L despite adequate fluid resuscitation. Sepsis is defined by the presence of a suspected or confirmed infectious source associated with organ dysfunction (neurological, respiratory, renal, hepatic, or hematological). \[Sepsis 3 criteria\]

You may not qualify if:

• Absence of central venous access.
• Central venous access not positioned in the superior vena cava (e.g., femoral access).

Sponsors & Collaborators

• Avicenna Military Hospital: lead

Study Sites (3)

Avicenna Military Hospital

Marrakesh, Marrakesh, 40000, Morocco

RECRUITING

Avicenna Military Hospital

Marrakesh, 40000, Morocco

RECRUITING

Department of critical care Medicine. Avicenna Military Hospital

Marrakesh, 40000, Morocco

RECRUITING

Related Publications (1)

• Ospina-Tascon GA, Madrinan HJ. Combination of O2 and CO2-derived variables to detect tissue hypoxia in the critically ill patient. J Thorac Dis. 2019 Jul;11(Suppl 11):S1544-S1550. doi: 10.21037/jtd.2019.03.52.

  PMID: 31388459 RESULT

MeSH Terms

Conditions

Shock, Septic; Sepsis

Condition Hierarchy (Ancestors)

Infections; Systemic Inflammatory Response Syndrome; Inflammation; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Shock

Study Officials

• Younes Aissaoui Pr

  Cadi Ayyad University. Faculty of Medicine and Pharmacy. Avicenna Military Hospital.

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Younes Aissaoui Professor of critical care medicine

CONTACT

+212661403332; younes.aissaoui@uca.ma

Ayoub Belhadj Professor of critical care medicine

CONTACT

+212670279562; ayoubbelhadj@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: December 26, 2024
• First Posted: July 31, 2025
• Study Start: January 5, 2025
• Primary Completion (Estimated): June 30, 2026
• Study Completion (Estimated): June 30, 2026
• Last Updated: March 31, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, CSR
• Time Frame: For 2 years after study completion.

Locations

MO (3)