Multiomics Profiling of CSF in Cardiac Arrest Survivors

NCT07090577 | Active Not Recruiting DMC

• 2 other identifiers: CNUH-202507010RS-2025-00554697
• Study Type: observational
• Target: 15
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this observational study is to identify further pathophysiologic mechanism of secondary brain injury following cardiac arrest by using serial multiomics profiling of serum and cerebrospinal fluid (CSF) samples. The main question it aims to answer is: A. The main question it aims to answer is: What are the dynamic molecular changes in serum and CSF that reflect the pathophysiological mechanisms of secondary brain injury after cardiac arrest? B. What are the differences in serum and CSF multiomic signatures between varying severities of cardiac arrest, and how are these differences associated with the underlying pathophysiological mechanisms of secondary brain injury? Serum and CSF samples that have already been prospectively collected from participants and stored in the BioBank will be used for this analysis.

Conditions

Cardiac Arrest (CA); Hypoxic-Ischemic Brain Injury; Post-Resuscitation Syndrome

Keywords

cardiac arrest; hypoxic-ischemic brain injury; post-resuscitation syndrome; multiomics; cerebrospinal fluid

Outcome Measures

Primary Outcomes (1)

• Neurological outcome

  Cerebral Performance Category (CPC) score

  after 6 months from return of spontaneous circulation

Secondary Outcomes (1)

• The Pittsburgh Cardiac Arrest Category (PCAC)

  immediately after return of spontaneous circulation

Study Arms (2)

good neurologic outcome

Cerebral Performance Category (CPC) : 1 or 2

poor neurologic outcome

Cerebral Performance Category (CPC) : 3 to 5

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients with an out-of-hospital cardiac arrest who underwent post-resuscitation care

You may qualify if:

• Age ≥ 18 years old
• Out-of-hospital cardiac arrest (OHCA)
• Patients who have received post-resuscitation care including temperature control due to unconsciousness (Glasgow Coma Score \< 8) after sustained ROSC.
• Patients who consented to the placement of lumbar catheter for storing cerebrospinal fluid and blood samples in a human biobank.

You may not qualify if:

• Patients diagnosed with a central nervous system-related disease before cardiac arrest
• Patients who have undergone extracorporeal circulatory membrane oxygenation therapy
• Patients who died within 24 hours from post-resuscitation care

Sponsors & Collaborators

• Chungnam National University Hospital: lead

Study Sites (1)

Chungnam National University Hospital

Daejeon, 35015, South Korea

Location

Related Publications (3)

• You Y, Park JS, Min JH, Jeong W, Ahn HJ, In YN, Jeon SY, Lee JK, Kang C. Blood-brain barrier permeability for the first 24 hours in hypoxic-ischemic brain injury following cardiac arrest. Resuscitation. 2024 May;198:110150. doi: 10.1016/j.resuscitation.2024.110150. Epub 2024 Feb 23.

  PMID: 38401708 BACKGROUND

• Stopa V, Lileikyte G, Bakochi A, Agarwal P, Beske R, Stammet P, Hassager C, Arman F, Nielsen N, Devaux Y. Multiomic biomarkers after cardiac arrest. Intensive Care Med Exp. 2024 Sep 27;12(1):83. doi: 10.1186/s40635-024-00675-y.

  PMID: 39331333 BACKGROUND

• Lileikyte G, Bakochi A, Ali A, Moseby-Knappe M, Cronberg T, Friberg H, Lilja G, Levin H, Arman F, Kjellstrom S, Dankiewicz J, Hassager C, Malmstrom J, Nielsen N. Serum proteome profiles in patients treated with targeted temperature management after out-of-hospital cardiac arrest. Intensive Care Med Exp. 2023 Jul 17;11(1):43. doi: 10.1186/s40635-023-00528-0.

  PMID: 37455296 BACKGROUND

MeSH Terms

Conditions

Heart Arrest; Hypoxia-Ischemia, Brain

Condition Hierarchy (Ancestors)

Heart Diseases; Cardiovascular Diseases; Brain Ischemia; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Hypoxia, Brain; Vascular Diseases; Hypoxia; Signs and Symptoms, Respiratory; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant professor

Study Record Dates

• First Submitted: July 21, 2025
• First Posted: July 29, 2025
• Study Start: July 22, 2025
• Primary Completion (Estimated): December 31, 2026
• Study Completion (Estimated): December 31, 2026
• Last Updated: July 29, 2025

Record last verified: 2025-07

Data Sharing

• IPD Sharing: Will not share

Locations

KR (1)