Acute Kidney Injury in Critical COVID-19: Outcomes and Risks

NCT07089693 | Completed

• 1 other identifier: İ05-257-22
• Study Type: observational
• Target: 238
• Locations: 1 country
• Sites: 1

Brief Summary

This retrospective observational study aims to determine the incidence of acute kidney injury (AKI) associated with COVID-19, risk factors, and effects on mortality for intensive care unit patients. Data from 238 COVID-19 patients monitored in the Anesthesiology and Reanimation Intensive Care Unit of Ankara University Ibni Sina Hospital between January 1, 2021 and January 1, 2022 were retrospectively reviewed. Patients were divided into two groups according to the level of renal damage (with and without AKI). Those with AKI were staged per the KDIGO criteria (Stage 1-2-3). Demographic data, comorbidities, Charlson comorbidity indexes, Acute Physiology and Chronic Health Evaluation scores, laboratory results, and mortality data were examined. The data obtained were compared between the groups. The findings may help improve clinical awareness and guide management strategies in intensive care unit patients with COVID-19 at risk of AKI

Conditions

COVID -19; Acute Kidney Injury; Intensive Care Unit (ICU) Admission; Mortality

Keywords

COVID-19; acute kidney injury; intensive care unit; risk factors; incidence

Outcome Measures

Primary Outcomes (1)

• Intensive care unit mortality

  To evaluate whether the development of AKI is associated with mortality in COVID-19 patients monitored in the intensive care unit.

  From ICU admission until in-hospital death or ICU discharge, whichever occurs first, assessed up to 90 days.

Secondary Outcomes (3)

• Length of intensive care unit stay

  From ICU admission until ICU discharge, assessed up to 12 months.

• Incidence of acute kidney injury

  From ICU admission until AKI diagnosis or ICU discharge, whichever occurs first, assessed during hospitalization (up to 100 days).

• Association between patient characteristics and AKI development

  From ICU admission until AKI diagnosis or ICU discharge, assessed up to 100 days.

Study Arms (4)

non-AKI

stage 1 AKI

stage 2 AKI

stage 3 AKI

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients (aged 18 and older) with PCR-confirmed COVID-19 who were admitted to the intensive care unit (ICU) at Ankara University Hospital between January 1,2021 and January 1,2022. All patients had available records and remained in the ICU for at least 48 hours.

You may qualify if:

• Age 18 years or older
• Hospitalized patients with COVID-19 confirmed by PCR test
• Required follow-up in the intensive care unit between January 1, 2021 and January 1, 2022

You may not qualify if:

• Patients with end-stage renal disease (ESRD)
• History of renal transplantation
• Intensive care unit stay shorter than 48 hours

Sponsors & Collaborators

• Ankara University: lead

Study Sites (1)

Ankara University

Ankara, 06230, Turkey (Türkiye)

Location

Related Publications (4)

• Arentz M, Yim E, Klaff L, Lokhandwala S, Riedo FX, Chong M, Lee M. Characteristics and Outcomes of 21 Critically Ill Patients With COVID-19 in Washington State. JAMA. 2020 Apr 28;323(16):1612-1614. doi: 10.1001/jama.2020.4326.

  PMID: 32191259 BACKGROUND

• Ratnayake A, Sarnowski A, Sinclair F, Annear NMP, Banerjee D, Chis Ster I. The dynamics and outcomes of AKI progression during the COVID-19 pandemic. Nephrology (Carlton). 2024 Jun;29(6):325-337. doi: 10.1111/nep.14297. Epub 2024 Mar 28.

  PMID: 38549280 BACKGROUND

• Guissouma J, Ben Ali H, Allouche H, Trabelsi I, Hammami O, Yahia Y, Hatem G. Acute Kidney Injury Complicating Critical Forms of COVID-19: risk Factors and Prognostic Impact. F1000Res. 2025 Jan 2;13:497. doi: 10.12688/f1000research.144105.3. eCollection 2024.

  PMID: 39839732 BACKGROUND

• Aklilu AM, Kumar S, Nugent J, Yamamoto Y, Coronel-Moreno C, Kadhim B, Faulkner SC, O'Connor KD, Yasmin F, Greenberg JH, Moledina DG, Testani JM, Wilson FP. COVID-19-Associated Acute Kidney Injury and Longitudinal Kidney Outcomes. JAMA Intern Med. 2024 Apr 1;184(4):414-423. doi: 10.1001/jamainternmed.2023.8225.

  PMID: 38407862 BACKGROUND

MeSH Terms

Conditions

COVID-19; Acute Kidney Injury

Condition Hierarchy (Ancestors)

Pneumonia, Viral; Pneumonia; Respiratory Tract Infections; Infections; Virus Diseases; Coronavirus Infections; Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections; Lung Diseases; Respiratory Tract Diseases; Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases

Study Officials

• Gizem Kahraman, MD

  Ankara University Department of Anesthesiology and Reanimation

  PRINCIPAL INVESTIGATOR

• Mustafa Kemal Bayar, Prof

  Ankara University Department of Anesthesiology and Reanimation

  STUDY DIRECTOR

• Pınar Karabak Bilal, MD

  Ankara University Department of Anesthesiology and Reanimation

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD, Intensive Care Specialist

Study Record Dates

• First Submitted: July 21, 2025
• First Posted: July 28, 2025
• Study Start: July 1, 2022
• Primary Completion: July 30, 2022
• Study Completion: August 15, 2022
• Last Updated: July 28, 2025

Record last verified: 2025-07

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)