Alveolar Ridge Preservation Using Autogenous Whole Tooth Graft With 1 %Metformin :A Randomized Controlled Clinical Trial
1 other identifier
interventional
24
1 country
1
Brief Summary
This study describes a technique used to preserve the bone dimensions after the tooth extraction inorder to facilitate later on the dental implant placement
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Jul 2025
Shorter than P25 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
July 18, 2025
CompletedFirst Posted
Study publicly available on registry
July 25, 2025
CompletedStudy Start
First participant enrolled
July 30, 2025
CompletedPrimary Completion
Last participant's last visit for primary outcome
September 30, 2025
CompletedStudy Completion
Last participant's last visit for all outcomes
March 30, 2026
CompletedJuly 25, 2025
July 1, 2025
2 months
July 18, 2025
July 18, 2025
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Radiographic buccolingual width ridge loss
Measuring the CBCT these dimensions pre operative and after 6 months
6 months
Secondary Outcomes (5)
Alveolar buccal ridge height, lingual ridge height
6 months
the area percentage of newly formed bone, soft tissue and residual graft
6 months
Patient satisfaction evaluation
2 weeks
Total number of analgesics taken in the first week
1 week
Socket wound healing score
2 weeks
Study Arms (2)
Test
EXPERIMENTALAutogenous Whole tooth graft + Metformin in the socket of extracted non-molar tooth
Control
ACTIVE COMPARATORAutogenous whole tooth graft
Interventions
Eligibility Criteria
You may qualify if:
- years or older
- patients requiring single extraction of non-molar tooth
- extraction sockets having more than 50% buccal alveolar bone loss
You may not qualify if:
- Pregnancy
- smokers
- patients not maintaing good oral hygiene
- presernce of acute endodontic infection in the tooth to be ectracted
- medical conditions hindering implant placement
- uncontrolled diabetes
- Immune suppression
- bisphosphanates
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Cairo Universitylead
Study Sites (1)
Cairo Univeristy
Giza, Egypt
Related Publications (1)
Elfana A, El-Kholy S, Saleh HA, Fawzy El-Sayed K. Alveolar ridge preservation using autogenous whole-tooth versus demineralized dentin grafts: A randomized controlled clinical trial. Clin Oral Implants Res. 2021 May;32(5):539-548. doi: 10.1111/clr.13722. Epub 2021 Mar 1.
PMID: 33565656BACKGROUND
Related Links
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- PARTICIPANT
- Masking Details
- The patients participating in this clinical trial
- Purpose
- OTHER
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Masters Degree Candidate
Study Record Dates
First Submitted
July 18, 2025
First Posted
July 25, 2025
Study Start
July 30, 2025
Primary Completion
September 30, 2025
Study Completion
March 30, 2026
Last Updated
July 25, 2025
Record last verified: 2025-07
Data Sharing
- IPD Sharing
- Will not share