Acute Exercise With Overdressing

NCT07080853 | Completed

• 1 other identifier: 23-14
• Study Type: interventional
• Target: 23
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to determine if exercise with extra clothing in a gym-like environment can increase body temperatures appropriately to help people adapt to the heat.

Conditions

Heat Stress, Exertional; Heat Acclimation and Thermotolerance

Keywords

Heat acclimation; Overdressing

Outcome Measures

Primary Outcomes (4)

• Core temperature

  Core temperature during exercise

  Up to 90 minutes

• Heart Rate

  Heart rate during exercise

  Up to 90 minutes

• Skin temperature

  Mean-weighted skin temperature during exercise

  Up to 90 minutes

• Whole-body sweat loss

  90 minutes

Study Arms (2)

Exercise with Overdressing

EXPERIMENTAL

Exercise with overdressing clothing ensemble

Other: Exercise with Overdressing

Control Exercise

ACTIVE COMPARATOR

Exercise with normal attire

Other: Control Exercise

Interventions

Exercise with Overdressing OTHER

Run for 30 minutes followed by walk for 60 minutes in a temperate (gym-like environment) wearing overdressing ensemble.

Exercise with Overdressing

Control Exercise OTHER

Run for 30 minutes followed by walk for 60 minutes in a temperate (gym-like environment) wearing control clothing ensemble.

Control Exercise

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Male or female, age 18-45
• Females must be premenopausal
• Body mass index 18.5-30.0 kg m-2
• In good health as determined by the Office of Medical Support \& Oversight (OMSO) General Medical Clearance
• Performs aerobic exercise at least 2 times per week and capable of running 2 miles in under 16:00 (8 minute mile pace)
• Willing to abstain from exercise and alcoholic beverages for 24 hours before each study visit.
• Willing to abstain from caffeine for 12 hours prior to all study visits.
• Willing to abstain from food for 2 hours prior to all study visits.
• Willing to abstain from nicotine/tobacco for at least 8 hours prior to all study visits.
• Have supervisor approval if permanent party military or a federal employee at U.S. Army Natick Soldier System Center

You may not qualify if:

• Females who are pregnant or planning to become pregnant during the study
• Taking dietary supplements, prescriptions, or over the counter medication, other than a contraceptive (unless approved by OMSO \& PI)
• Abnormal blood count during OMSO medical screening (For example: hemoglobin (Hb) outside of the typical normal values reported by LabCorp in accordance with OMSO (Normal \[Hb\] Males = 12.6-17.7 g/dL; Females = 11.1-15.9 g/dL) or hematocrit (Hct) outside of the normal ranges (Normal Hct Males = 37.5-51.0%; Females = 34.0-46.6%) levels, presence of abnormal blood chemicals (hemoglobin S or sickle cell traits)
• Any history of pulmonary or cardiovascular disease
• Any history of asthma
• Current or recent respiratory tract or sinus infections (\< 1 month prior)
• History of heat intolerance or orthostatic intolerance
• Diagnosed and/or treated for fluid/electrolyte imbalance within the last 30 days
• History of obstructive disease of the gastrointestinal tract including (but not limited to) diverticulosis, diverticulitis and inflammatory bowel disease, peptic ulcer disease, Crohn's disease, ulcerative colitis.
• Scheduled MRI during testing
• Allergies to adhesives (e.g., medical tape).

Sponsors & Collaborators

• United States Army Research Institute of Environmental Medicine: lead

Study Sites (1)

US Army Research Institute of Environmental Medicine

Natick, Massachusetts, 01760, United States

Location

MeSH Terms

Conditions

Heat Stress Disorders

Interventions

Exercise

Condition Hierarchy (Ancestors)

Wounds and Injuries

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Benjamin J Ryan, PhD

  United States Army Research Institute of Environmental Medicine

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: OTHER
• Intervention Model: CROSSOVER
• Sponsor Type: FED
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 2, 2025
• First Posted: July 23, 2025
• Study Start: June 22, 2023
• Primary Completion: April 28, 2025
• Study Completion: April 28, 2025
• Last Updated: December 24, 2025

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)