Evaluation of Right Ventricular Function to Predict Weaning Success in the Intensive Care Unit

NCT07073976 | Recruiting

• 1 other identifier: Weaning-Right Heart
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this prospective observational study is to evaluate whether right ventricular (RV) function parameters assessed via transthoracic echocardiography (TTE) can predict weaning success in adult intensive care unit (ICU) patients who are mechanically ventilated. The main questions it aims to answer are: Can the TAPSE (Tricuspid Annular Plane Systolic Excursion) value predict successful extubation? Do other right heart parameters (tricuspid S', RV-FAC, right atrial area, pulmonary valve acceleration time) provide additional prognostic value for weaning outcomes? Participants will: Be adult ICU patients planned for weaning from mechanical ventilation. Undergo transthoracic echocardiography within 2 hours after meeting clinical weaning criteria. Have the following echocardiographic parameters measured: TAPSE, tricuspid S', RV-FAC, right atrial area, and pulmonary valve acceleration time. Be monitored for 24 hours after extubation to assess weaning success (defined as no need for reintubation, non-invasive ventilation, or high-flow oxygen support).

Conditions

Weaning Failure of Mechanical Ventilation

Outcome Measures

Primary Outcomes (1)

• Discriminative Ability of TAPSE for Predicting Weaning Success

  Assessment of the predictive accuracy of TAPSE (Tricuspid Annular Plane Systolic Excursion) in identifying weaning success, defined as no requirement for reintubation, non-invasive ventilation, or high-flow oxygen within 24 hours post-extubation.

  Within 24 hours after extubation

Secondary Outcomes (4)

• Discriminative Ability of RV-FAC in Predicting Weaning Success

  Within 24 hours after extubation

• Discriminative Ability of Tricuspid S' Velocity in Predicting Weaning Success

  Within 24 hours after extubation

• Correlation of Right Atrial Area With Weaning Outcome

  Within 24 hours after extubation

• Correlation of Pulmonary Valve Acceleration Time with Predicting Weaning Success

  Within 24 hours after extubation

Study Arms (1)

Mechanically Ventilated ICU Patients Undergoing Weaning

Adult patients receiving mechanical ventilation in the intensive care unit (ICU) who meet clinical criteria for planned weaning and extubation. All patients will undergo bedside transthoracic echocardiography (TTE) to assess right ventricular function prior to extubation.

Diagnostic Test: Transthoracic Echocardiography (TTE)

Interventions

Transthoracic Echocardiography (TTE) DIAGNOSTIC_TEST

Non-invasive ultrasound imaging of the heart to evaluate right ventricular and right atrial function using parameters such as TAPSE, tricuspid S', RV-FAC, right atrial area, and pulmonary valve acceleration time. TTE will be performed once within 2 hours prior to extubation decision as part of routine care.

Mechanically Ventilated ICU Patients Undergoing Weaning

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Adult patients who are receiving invasive mechanical ventilation in the intensive care unit (ICU) and are scheduled for planned extubation based on standard clinical weaning criteria. All participants must be hemodynamically stable and able to undergo transthoracic echocardiographic assessment prior to extubation.

You may qualify if:

• Receiving invasive mechanical ventilation in the ICU
• Planned extubation (weaning) according to standard clinical criteria
• Hemodynamically stable at the time of transthoracic echocardiography (TTE)
• Ability to undergo echocardiographic assessment within 2 hours prior to extubation
• Informed consent obtained from patient or legal representative

You may not qualify if:

• Known severe tricuspid valve disease or congenital heart disease
• Moderate to severe pericardial effusion or cardiac tamponade
• Inadequate acoustic window for transthoracic echocardiography
• Patients requiring urgent or unplanned extubation
• Use of extracorporeal life support (e.g., ECMO) at the time of assessment
• Known pulmonary embolism or acute cor pulmonale
• Pregnancy

Sponsors & Collaborators

• Kanuni Sultan Suleyman Training and Research Hospital: lead

Study Sites (1)

Health Science University İstanbul Kanuni Sultan Süleyman Education and Training Hospital

Istanbul, Istanbul, 34303, Turkey (Türkiye)

RECRUITING

MeSH Terms

Interventions

Echocardiography

Intervention Hierarchy (Ancestors)

Cardiac Imaging Techniques; Diagnostic Imaging; Diagnostic Techniques and Procedures; Diagnosis; Ultrasonography; Heart Function Tests; Diagnostic Techniques, Cardiovascular

Central Study Contacts

Engin ihsan Turan, principal investigator

CONTACT

+905382431114; enginihsan@hotmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 1 Day
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: principal investigator

Study Record Dates

• First Submitted: July 10, 2025
• First Posted: July 20, 2025
• Study Start: July 31, 2025
• Primary Completion (Estimated): July 15, 2026
• Study Completion (Estimated): July 16, 2026
• Last Updated: September 9, 2025

Record last verified: 2025-07

Locations

TU (1)