Use of Diaphragm Ultrasound and Evaluation of Respiratory Parameters in Determining Weaning Success in Geriatric Patients

NCT07044063 | Completed

• 1 other identifier: DLKTRH-ANS-IYK-01
• Study Type: observational
• Target: 44
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to evaluate the effectiveness of ultrasound-based diaphragmatic measurements in predicting weaning success in patients aged 65 and older who are receiving mechanical ventilation. Additionally, it seeks to contribute to the clinical decision-making process by examining the relationship between these measurements and conventional weaning parameters.

Conditions

Weaning Failure of Mechanical Ventilation; Diaphragm Ultrasonography; Geriatric

Keywords

diaphragm; ultrasound; geriatric; weaning; mechanical ventilation

Outcome Measures

Primary Outcomes (3)

• Diaphragm Thickness Measurement

  Diaphragm thicknesses are measured with linear ultrasound probe at 8-10th intercostal space on anterior or middle axillary line using B-mode during inspiration and expiration.

  Within 24 hours prior to weaning from mechanical ventilation.

• Diaphragmatic Excursion Measurement

  Diaphragmatic excursion is measured with convex probe at midclavicular line just below costal arch using M-mode during respiratory cycle.

  Within 24 hours prior to weaning from mechanical ventilation.

• Diaphragm Thickening Fraction

  Diaphragmatic thickening fraction is calculated by taking the difference between diaphragm thickness at end-inspiration and diaphragm thickness at end-expiration, dividing it by the thickness at end-expiration, and multiplying by 100 to get a percentage.

  Within 24 hours prior to weaning from mechanical ventilation.

Secondary Outcomes (9)

• Arterial Blood Gas

  Within 24 hours prior to weaning from mechanical ventilation.

• Oxygen Saturation

  Within 24 hours prior to weaning from mechanical ventilation

• Respiratory Rate (Breaths per Minute)

  Within 24 hours prior to weaning from mechanical ventilation

• Rapid Shallow Breathing Index (Breath/Minute/L)

  Within 24 hours prior to weaning from mechanical ventilation

• Mechanical Ventilation Duration (Hours)

  Within 24 hours prior to weaning from mechanical ventilation

Study Arms (2)

Weaning Success Group

Patients who are weaned from mechanical ventilation within 24 hours of diaphragmatic ultrasound measurements and didn't need mechanical ventilation again for at least 48 hours was placed in this group.

Weaning Failure Group

Patients who are weaned from mechanical ventilation within 24 hours of diaphragmatic ultrasound measurements but needed mechanical ventilation support again within 48 hours after weaning was placed in this group.

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients admitted to the intensive care unit of Kartal Dr. Lutfi Kirdar Training and Research Hospital who are 65 years or older and underwent mechanical ventilation

You may qualify if:

• years and older
• Admitted to ICU
• Intubated and mechanically ventilated for at least 24 hours
• Clinically decided to wean from mechanical ventilation

You may not qualify if:

• Those who have mechanically ventilated for more than 14 days
• Those who have been tracheostomized
• Those with preexisting diaphragm or lung pathologies
• Those who had cardiothoracic surgery
• Those with muscular or musculoskeletal diseases
• Those with Glasgow Coma Scale lower than 10T without sedation

Sponsors & Collaborators

• Dr. Lutfi Kirdar Kartal Training and Research Hospital: lead

Study Sites (1)

University of Health Sciences Kartal Dr. Lutfi Kirdar City Hospital

Istanbul, 34865, Turkey (Türkiye)

Location

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Resident Doctor

Study Record Dates

• First Submitted: April 9, 2025
• First Posted: June 29, 2025
• Study Start: December 1, 2023
• Primary Completion: May 1, 2024
• Study Completion: May 1, 2024
• Last Updated: June 29, 2025

Record last verified: 2025-04

Locations

TU (1)