Speckle Tracking Echocardiography for the Prediction of Weaning Failure

NCT03657524 | Recruiting

• 1 other identifier: 2018-34
• Study Type: interventional
• Target: 110
• Locations: 1 country
• Sites: 1

Brief Summary

Deciding the optimal timing for extubation in patients who are mechanically ventilated can be challenging, and traditional weaning predictor tools are not accurate. Recent studies suggest that isolated sonographic assessment of the respiratory and cardiac function (ie diastolic function and filling pressure), in mechanically ventilated patients may assist in identifying patients at risk of weaning failure. Recently, the association of conventional echocardiography and lung ultrasound showed promising results for the prediction of post extubation distress. Speckle Tracking is an emerging tool in intensive care medicine that has never been investiguated for the prediction of weaning failure. It could early detects diastolic dysfunction and and elevated filling pressure. Of more, speckle tracking is known to be less operator dependant. The main objective of our study is to evaluate the diagnosis accuracy of speckle tracking echocardiography performed during a weaning trial to predict weaning failure. The secondary objectives are to assess the diagnosis accuracy of combined heart and lung ultrasound to predict weaning failure.

Conditions

Weaning Failure of Mechanical Ventilation

Outcome Measures

Primary Outcomes (1)

• lung and heart ultrasounds

  Area under the receiver operator characteristic curve (AUC) of global longitudinal strain and strain rate variations (before and during a weaning trial) to predict weaning failure.

  Just before and during the weaning trial

Study Arms (2)

Resuscitation patients

EXPERIMENTAL

Other: echocardiography

healthy volunteers

ACTIVE COMPARATOR

Other: echocardiography

Interventions

echocardiography OTHER

Speckle tracking echocardiography

Resuscitation patients; healthy volunteers

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• \- Patients hospitalized in intensive care unit under mechanical fulfilling the criteria of ventilation weaning trial.

You may not qualify if:

• Less than 18 years old.
• Pregnancy
• Non sinusal cardiac rhythm
• Neuro Myopathy
• Tracheotomy
• Lack of echogenicity to perform at least a four chamber apical view

Sponsors & Collaborators

• Assistance Publique Hopitaux De Marseille: lead

Study Sites (1)

Assistance Publique Hôpitaux de Marseille

Marseille, 13015, France

RECRUITING

Study Officials

• Jean-Olivier ARNAUD

  Assistance Publique Hôpitaux de Marseille

  STUDY DIRECTOR

Central Study Contacts

Laurent ZIELESKIEWICZ

CONTACT

04 91 96 53 77; laurent.zieleskiewicz@ap-hm.fr

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 31, 2018
• First Posted: September 5, 2018
• Study Start: May 20, 2019
• Primary Completion: May 21, 2026
• Study Completion: May 21, 2026
• Last Updated: February 12, 2026

Record last verified: 2026-02

Locations

FR (1)